Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects
Mori TA, Woodman RJ, Burke V, Puddey IB, Croft KD, Beilin LJ
Free radical biology & medicine · 238 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Medical Research Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2003-10-01 · Free Radic Biol Med · vol. 35 · número 7 · págs. 772–781
- Editorial
- Elsevier BV
- Citado
- 322 citas · más que el 99% de estudios similares · 14.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Edible Oils Quality and Analysis
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, omega-3 supplementation, F2-isoprostanes, lipid peroxidation, oxidative stress, inflammation, type 2 diabetes, hypertension, C-reactive protein, interleukin-6, TNF-α, HbA1c, olive oil
- MeSH
- humans, hypertension, diabetes mellitus, diabetes complications, inflammation, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, f2-isoprostanes, phospholipids, plant oils, diet, fasting, oxidative stress, adult, aged, middle aged, female, male, biomarkers, olive oil
6 autores
- Trevor Anthony Mori🇦🇺 · autor de correspondenciaThe University of Western Australia; Harry Perkins Institute of Medical Research
- Richard John Woodman🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Valerie Burke🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Ian B. Puddey🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Kevin D. Croft🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
n-3 fatty acids reduce the risk of cardiovascular disease via a number of possible mechanisms. Despite this, there has been concern that these fatty acids may increase lipid peroxidation. The data in vivo are inconclusive, due in part to limitations in the methodologies. In this regard, the measurement of F2-isoprostanes provides a reliable assessment of in vivo lipid peroxidation and oxidant stress. This study aimed to assess the effects of supplementation with purified eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), the two major n-3 fatty acids, on urinary F2-isoprostanes and markers of inflammation, in type 2 diabetic patients. In a double-blind, placebo controlled trial of parallel design, 59 nonsmoking, treated-hypertensive, type 2 diabetic subjects, were randomized to 4 g daily of purified EPA, DHA, or olive oil for 6 weeks, while maintaining their usual diet. F2-isoprostanes, measured using gas chromatography-mass spectrometry in 24 h urines and C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), were measured before and after intervention. Thirty-nine men and 12 women aged 61.2 +/- 1.2 years, with body mass index (BMI), 29.5 +/- 0.5 kg/m2; 24 h blood pressure, 138/73 mmHg; HbA1c, 7.3 +/- 0.1% and fasting glucose, 7.9 +/- 0.2 mmol/l completed the intervention. Baseline urinary F2-isoprostanes were positively associated with HbA1c (p=.011) and fasting glucose (p=.032). Relative to the olive oil group, postintervention urinary F2-isoprostanes were decreased 19% by EPA (p=.017) and 20% by DHA (p=.014). There were no significant changes in CRP, IL-6, and TNF-alpha following EPA or DHA supplementation. In regression analysis, Delta F2-isoprostanes were positively associated with Delta HbA1c (p=.007) independent of treatment group; and with Delta TNF-alpha (p=.034) independent of age, gender, BMI, and treatment group. There were no associations with Delta CRP or Delta IL-6. This study is the first report demonstrating that either EPA or DHA reduce in vivo oxidant stress without changing markers of inflammation, in treated hypertensive, type 2 diabetic subjects.
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