Effect of creatine and weight training on muscle creatine and performance in vegetarians
Burke DG, Chilibeck PD, Parise G, Candow DG, Mahoney D, Tarnopolsky M
Medicine and science in sports and exercise · 124 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-11-01 · Med Sci Sports Exerc · vol. 35 · número 11 · págs. 1946–1955
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 224 citas · más que el 83% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Biochemical effects in animals
- Palabras clave
- creatine supplementation, resistance training, vegetarians, muscle creatine, phosphocreatine, exercise performance, lean body mass, muscle fiber morphology, hydration status, ergogenic aids, protein restriction
- MeSH
- muscle, skeletal, humans, creatine, diet, vegetarian, physical education and training, weight lifting, adult, middle aged, female, male
6 autores
- DARREN G. BURKE🇨🇦St. Francis Xavier University
- Philip David Chilibeck🇨🇦University of Saskatchewan
- Gianni Parise
- Darren Glenn Candow🇨🇦University of Saskatchewan
- Douglas J. Mahoney🇨🇦McMaster University
- Mark Andrew Tarnopolsky🇨🇦McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To compare the change in muscle creatine, fiber morphology, body composition, hydration status, and exercise performance between vegetarians and nonvegetarians with 8 wk of creatine supplementation and resistance training.
Methods
Eighteen VG and 24 NV subjects (19-55 yr) were randomly assigned (double blind) to four groups: VG + creatine (VGCr, N=10), VG + placebo (VGPl, N=8), NV + creatine (NVCr, N=12), and NV + placebo (NVPl, N=12). Before and at the end of the study, muscle biopsies were taken from the vastus lateralis m, body composition was assessed by DXA, and strength was assessed using 1-RM bench press and leg press. Subjects participated in the same 8-wk resistance-training program. Creatine dosage was based on lean tissue mass (0.25 g.kg(-1) LTM.d(-1) x 7 d; 0.0625 g.kg(-1) LTM.d(-1) x 49 d).
Results
Biopsy samples indicated that total creatine (TCr=free Cr + PCr) was significantly lower in VG compared with NV at baseline (VG=117 mmol.kg(-1); NV=130 mmol.kg(-1); P<0.05). For Cr subjects, there was a greater increase in PCr, TCr, bench-press strength, isokinetic work, Type II fiber area, and whole-body lean tissue compared with subjects on placebo (P<0.05). Vegetarians who took Cr had a greater increase in TCr, PCr, lean tissue, and total work performance than nonvegetarians who took Cr (P<0.05). The change in muscle TCr was significantly correlated with initial muscle TCr, and the change in lean tissue mass and exercise performance. These findings confirm an ergogenic effect of Cr during resistance training and suggest that subjects with initially low levels of intramuscular Cr (vegetarians) are more responsive to supplementation.
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