Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial
Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, Prescott SL
The Journal of allergy and clinical immunology · 316 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-12-01 · J Allergy Clin Immunol · vol. 112 · número 6 · págs. 1178–1184
- Editorial
- Elsevier BV
- Citado
- 520 citas · más que el 100% de estudios similares · 20.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Food Allergy and Anaphylaxis Research · Asthma and respiratory diseases
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, maternal supplementation, pregnancy, atopy prevention, infant allergy, atopic dermatitis, cytokine response, erythrocyte membrane fatty acids, skin prick test, egg allergy, cat allergy
- MeSH
- erythrocyte membrane, fetal blood, humans, asthma, dermatitis, atopic, dietary fats, unsaturated, fatty acids, omega-3, fish oils, allergens, cytokines, risk factors, lymphocyte activation, antibody formation, gestational age, pregnancy, maternal-fetal exchange, dietary supplements, adult, infant, female
7 autores
- Janet A. Dunstan🇦🇺The University of Western Australia
- Trevor Anthony Mori🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Anne E. Barden🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Angie L. Taylor🇦🇺The University of Western Australia
- Patrick G. Holt🇦🇺The Kids Research Institute Australia
- Susan L. Prescott🇦🇺The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is growing interest in the potential role of anti-inflammatory n-3 polyunsaturated fatty acids (n-3 PUFAs) in the prevention of allergic disease.
Objective
We sought to determine whether maternal dietary supplementation with n-3 PUFAs during pregnancy could modify immune responses in infants.
Methods
In a randomized, controlled trial 98 atopic, pregnant women received fish oil (3.7 g n-3 PUFAs per day) or placebo from 20 weeks' gestation until delivery. Neonatal PUFA levels and immunologic response to allergens were measured at birth.
Results
Eighty-three women completed the study. Fish oil supplementation (n = 40) achieved significantly higher proportions of n-3 PUFAs in neonatal erythrocyte membranes (mean +/- SD, 17.75% +/- 1.85% as a percentage of total fatty acids) compared with the control group (n = 43, 13.69% +/- 1.22%, P <.001). All neonatal cytokine (IL-5, IL-13, IL-10, and IFN-gamma) responses (to all allergens) tended to be lower in the fish oil group (statistically significant only for IL-10 in response to cat). Although this study was not designed to examine clinical effects, we noted that infants in the fish oil group were 3 times less likely to have a positive skin prick test to egg at 1 year of age (odds ratio, 0.34; 95% confidence interval, 0.11 to 1.02; P =.055). Although there was no difference in the frequency of atopic dermatitis at 1 year of age, infants in the fish oil group also had significantly less severe disease (odds ratio, 0.09; 95% confidence interval, 0.01 to 0.94; P =.045).
Conclusions
These data suggest a potential reduction in subsequent infant allergy after maternal PUFA supplementation. More detailed follow-up studies are required in larger cohorts to establish the robustness of these findings and to ascertain their significance in relation to longer-term modification of allergic disease in children.
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