Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein
Sánchez-Muniz FJ, Oubiña P, Ródenas S, Benedi J, Cuesta C
European journal of nutrition · 9 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-12-01 · Eur J Nutr · vol. 42 · número 6 · págs. 299–306
- Editorial
- Springer Science+Business Media
- Citado
- 15 citas · más que el 65% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Platelet Disorders and Treatments · Inflammatory mediators and NSAID effects
- Palabras clave
- platelet aggregation, thromboxane B2, prostacyclin, high oleic sunflower oil, palmitic acid, saturated fatty acids, dietary fat, postmenopausal women, cholesterol, eicosanoids, 6-keto-prostaglandin F1alpha, LDL cholesterol, HDL cholesterol, tocopherols
- MeSH
- humans, peroxides, cholesterol, dietary fats, unsaturated, dinoprost, epoprostenol, thromboxane b2, oleic acid, lipoproteins, plant oils, alpha-tocopherol, antioxidants, cross-over studies, postmenopause, platelet aggregation, aged, middle aged, female, cholesterol, ldl, cholesterol, hdl, palm oil, sunflower oil
5 autores
- Francisco José Sánchez-Muniz🇪🇸Universidad Complutense de Madrid
- Pilar Oubi�a🇪🇸Universidad Complutense de Madrid
- Sof�a R�denas
- Juana Benedı́🇪🇸Universidad Complutense de Madrid
- Carmen Cuesta🇪🇸Universidad Complutense de Madrid
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Saturated fatty acids exert controversial effects on platelet aggregation and eicosanoid production.
Aim
To investigate the effect of a dietary exchange between palmitic acid and oleic acid on both platelet aggregation and thromboxane B2 (TXB(2)) production, and on urine TXB(2), prostacyclin I2 (PGI(2) as 6-keto-protaglandin F(1)alpha), and the thrombogenic ratio (TXB(2)/6-keto-protaglandin F(1)alpha) in fourteen postmenopausal women.
Experimental design
Women were assigned to two consecutive 28-d dietary periods that were high in cholesterol (~400 mg/d) and fat (~46%en). In the first period all subjects followed an oleic acid-rich diet prepared with high oleic acidsunflower oil. This was followed by a second period rich in palmitic acid in the form of palmolein. DETERMINATIONS: Nutrient intakes, ADP-platelet aggregation, platelet TXB(2) production, urine TXB(2) and 6-keto-protaglandin F(1)alpha were measured during two dietary periods and the results obtained correlated to serum cholesterol, lipoproteincholesterol and peroxides, apolipoproteins and plasma tocopherol.
Results
The palmolein diet led to an increase in the platelet aggregation rate (p or = 6.2 mmol/L) or age ( or = 65 yr).
Conclusions
Palmolein diet activates platelet aggregation more in normocholesterolemics. Though palmolein increased thromboxane and tended to increase prostacyclin in urine in normo- and hypercholesterolemic women, the thrombogenic ratio did not change. These effects were related to the LDL and HDL concentration increases and to the absence of change in the total cholesterol/HDL-cholesterol ratio found following the dietary intervention.
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