Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men
Kenny AM, Biskup B, Robbins B, Marcella G, Burleson JA
Journal of the American Geriatrics Society · 115 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Center for Research Resources
- Gobierno
- NIA NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute on Aging (5P60AG13631); National Center for Research Resources (M01 RR 06192)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2003-11-20 · J Am Geriatr Soc · vol. 51 · número 12 · págs. 1762–1767
- Editorial
- Wiley
- Citado
- 176 citas · más que el 92% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, vitamin D3, older men, muscle strength, muscle power, physical performance, physical activity, health perception, 25-hydroxyvitamin D, parathyroid hormone, ionized calcium, calcium supplementation, community-dwelling older adults
- MeSH
- humans, 25-hydroxyvitamin d 2, vitamin d, double-blind method, health status, physical fitness, aged, aged, 80 and over, male, biomarkers
5 autores
- Rose Anne Kenny🇺🇸 · autor de correspondenciaUConn Health
- Bradley Biskup🇺🇸UConn Health
- Bertha Robbins🇺🇸UConn Health
- Glenn Marcella🇺🇸UConn Health
- Joseph A. Burleson🇺🇸UConn Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To study the effects of vitamin D supplementation in healthier populations of men.
Design
: Randomized, controlled trial.
Setting
General clinical research center.
Participants
Sixty-five healthy, community-dwelling men (mean age+/-standard deviation=76+/-4, range 65-87).
Intervention
Cholecalciferol (1,000 IU/d) or placebo supplementation for 6 months; all received 500 mg supplemental calcium.
Measurements
Upper and lower extremity muscle strength and power, physical performance and activity, health perception, calcium and vitamin D intake, and biochemical assessment, including 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and ionized calcium levels.
Results
The levels of 25OHD increased and PTH decreased in the cholecalciferol group, whereas there were no significant changes in the control group (P<.001). Baseline 25OHD levels correlated with baseline single-leg stance time and physical activity score. Baseline PTH levels correlated with baseline 8-foot walk time and physical activity score. No significant difference in strength, power, physical performance, or health perception was found between groups.
Conclusion
The 25OHD or PTH levels correlated with physical activity and physical performance in older, community-dwelling men with normal 25OHD status. Vitamin D supplementation increased 25OHD levels and decreased PTH levels but did not increase muscle strength or improve physical performance or health perception in this group of healthy, older men. Further investigations of the effects of vitamin D supplementation should focus on individuals with low levels of vitamin D.
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