A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham Neck of Femur (NONOF) Study
Harwood RH, Sahota O, Gaynor K, Masud T, Hosking DJ, Nottingham Neck of Femur (NONOF) Study
Age and ageing · 143 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-12-28 · Age Ageing · vol. 33 · número 1 · págs. 45–51
- Editorial
- Oxford University Press
- Citado
- 225 citas · más que el 96% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Hip and Femur Fractures
- Palabras clave
- hip fracture, calcium supplementation, vitamin D supplementation, vitamin D3, secondary fracture prevention, older women, bone mineral density, bone turnover markers, parathyroid hormone, 25-hydroxyvitamin D, falls
- MeSH
- humans, hip fractures, recurrence, calcium, vitamin d, follow-up studies, bone density, aged, aged, 80 and over, female
5 autores
- Rowan Harwood🇬🇧 · autor de correspondenciaQueen's Medical Centre
- Opinder Sahota🇬🇧Queen's Medical Centre
- Kathy Gaynor🇬🇧Queen's Medical Centre
- Tahir Masud🇬🇧Nottingham City Hospital; Queen's Medical Centre
- D. J. Hosking🇬🇧Nottingham City Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
survivors of hip fracture are at 5- to 10-fold risk of a second hip fracture. There is little consensus about secondary prevention. Many are given calcium and vitamin D, but the evidence supporting this is circumstantial.
Objective
to compare the effects of different calcium and vitamin D supplementation regimens on bone biochemical markers, bone mineral density and rate of falls in elderly women post-hip fracture.
Design
randomised controlled trial.
Setting
orthogeriatric rehabilitation ward.
Methods
150 previously independent elderly women, recruited following surgery for hip fracture, were assigned to receive a single injection of 300,000 units of vitamin D(2), injected vitamin D(2) plus 1 g/day oral calcium, 800 units/day oral vitamin D(3) plus 1 g/day calcium, or no treatment. Follow-up was one year, with measurement of 25-hydroxyvitamin D, parathyroid hormone, bone mineral density, and falls.
Results
mean 25-hydroxyvitamin D increased and mean parathyroid hormone was suppressed in all the actively treated groups, more so in the group receiving combined oral vitamin D and calcium. Twenty per cent of participants injected with vitamin D were deficient in 25-hydroxyvitamin D a year later. Bone mineral density showed small but statistically significant differences of up to 4.6% between actively treated groups and placebo. Relative risk of falling in the groups supplemented with vitamin D was 0.48 (95% CI 0.26-0.90) compared with controls.
Conclusion
Vitamin D supplementation, either orally or with injected vitamin D, suppresses parathyroid hormone, increases bone mineral density and reduces falls. Effects may be more marked with calcium co-supplementation. The 300,000 units of injected vitamin D may not last a whole year.
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