Bone and gastric bypass surgery: effects of dietary calcium and vitamin D
Goode LR, Brolin RE, Chowdhury HA, Shapses SA
Obesity research · 142 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- New Jersey Agricultural Experiment Station
Según 1 financiador declarado.
Publicación
- Publicado
- 2004-01-01 · Obes Res · vol. 12 · número 1 · págs. 40–47
- Editorial
- Wiley
- Citado
- 233 citas · más que el 99% de estudios similares · 18.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Bone health and osteoporosis research · Bariatric Surgery and Outcomes · Vitamin D Research Studies
- Palabras clave
- Roux-en-Y gastric bypass, bariatric surgery, bone mineral density, bone mineral content, calcium supplementation, vitamin D supplementation, secondary hyperparathyroidism, parathyroid hormone, bone resorption, postmenopausal women, bone loss, obesity
- MeSH
- bone and bones, humans, obesity, weight loss, calcium, dietary, parathyroid hormone, vitamin d, gastric bypass, diet, follow-up studies, bone remodeling, postmenopause, premenopause, bone density, dietary supplements, adult, middle aged, female
4 autores
- Lisa R. Goode🇺🇸Rutgers, The State University of New Jersey
- Robert E. Brolin🇺🇸Saint Peter's University Hospital
- Hasina Akhter Chowdhury🇺🇸Rutgers, The State University of New Jersey
- Sue A. Shapses🇺🇸 · autor de correspondenciaRutgers, The State University of New Jersey
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine bone mass and metabolism in women who had previously undergone Roux-en-Y gastric bypass (RYGB) and determine the effect of supplementation with calcium (Ca) and vitamin D.
Research methods and procedures
Bone mineral density and bone mineral content (BMC) were examined in 44 RYGB women (> or = 3 years post-surgery; 31% weight loss; BMI, 34 kg/m(2)) and compared with age- and weight-matched control (CNT) women (n = 65). In a separate analysis, RYGB women who presented with low bone mass (n = 13) were supplemented to a total 1.2 g Ca/d and 8 microg vitamin D/d over 6 months and compared with an unsupplemented CNT group (n = 13). Bone mass and turnover and serum parathyroid hormone (PTH) and 25-hydroxyvitamin D were measured.
Results
Bone mass did not differ between premenopausal RYGB and CNT women (42 +/- 5 years), whereas postmenopausal RYGB women (55 +/- 7 years) had higher bone mineral density and BMC at the lumbar spine and lower BMC at the femoral neck. Before and after dietary supplementation, bone mass was similar, and serum PTH and markers of bone resorption were higher (p < 0.001) in RYGB compared with CNT women and did not change significantly after supplementation.
Discussion
Postmenopausal RYGB women show evidence of secondary hyperparathyroidism, elevated bone resorption, and patterns of bone loss (reduced femoral neck and higher lumbar spine) similar to other subjects with hyperparathyroidism. Although a modest increase in Ca or vitamin D does not suppress PTH or bone resorption, it is possible that greater dietary supplementation may be beneficial.
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