Long-term magnesium supplementation in essential hypertension
Ferrara LA, Iannuzzi R, Castaldo A, Iannuzzi A, Dello Russo A, Mancini M
Cardiology · 33 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-11-14 · Cardiology · vol. 81 · número 1 · págs. 25–33
- Editorial
- Karger Publishers
- Citado
- 57 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Blood Pressure and Hypertension Studies · Magnesium Oxide Properties and Applications
- Palabras clave
- magnesium supplementation, essential hypertension, blood pressure, sympathetic stimulation, cold pressor test, isometric exercise, tilt table test, peripheral blood flow, systemic vascular resistance, urinary magnesium excretion, serum magnesium
- MeSH
- humans, hypertension, magnesium, pyrrolidonecarboxylic acid, antihypertensive agents, exercise test, double-blind method, blood pressure, time factors, adult, middle aged, female, male
6 autores
- Liberato Aldo Ferrara🇮🇹University of Campania "Luigi Vanvitelli"; University of Naples Federico II
- R. Iannuzzi🇮🇹University of Naples Federico II
- Anna Castaldo🇮🇹University of Naples Federico II
- Arcangelo Iannuzzi🇮🇹University of Naples Federico II
- Dello Russo🇮🇹Centro Cardiologico Monzino
- Mario Mancini🇮🇹University of Naples Federico II
Resumen
El texto original del estudio, en el idioma en que se publicó.
The main objective of this clinical trial was to evaluate the effects of magnesium pidolate (15 mmol/day) on blood pressure at rest and during sympathetic stimulation induced by cold, isometric and tilt test; peripheral blood flow has been evaluated by strain-gauge plethysmography. Fourteen mild to moderate hypertensives (8 males, 6 females, age range 40-60 years) were randomly given magnesium or placebo in a double-blind parallel clinical trial for 6 months. In the actively treated group magnesium urinary excretion increased from 5.3 +/- 2 to 7.7 +/- 2 mmol/24 h, and serum magnesium changed from 0.9 +/- 0.1 to 1.0 +/- 0.2 mmol/l. On magnesium, BP changed at rest from 156/97 +/- 12/4 to 149/90 +/- 8/3 mm Hg, during cold pressor test from 169/105 +/- 9/6 to 174/105 +/- 15/4, during isometric exercise from 170/107 +/- 13/9 to 170/105 +/- 20/6, and during tilt test from 149/96 +/- 11/6 to 153/96 +/- 17/7 mm Hg. Similar changes were observed in the placebo group. Peripheral resistances were 14.7 +/- 4 and 9.8 +/- 2 PRU before and after magnesium, respectively. These data indicate that long-term magnesium pidolate supplementation does not affect blood pressure at rest and during sympathetic stimulation, despite a slight, nonsignificant reduction in forearm peripheral resistance.
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