Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption
Lovallo WR, Wilson MF, Vincent AS, Sung BH, McKey BS, Whitsett TL
Hypertension (Dallas, Tex. : 1979) · 57 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-32050-S2); National Heart, Lung, and Blood Institute (HL32050); National Heart, Lung, and Blood Institute (HL07640)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2004-02-17 · Hypertension · vol. 43 · número 4 · págs. 760–765
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 105 citas · más que el 96% de estudios similares · 5.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Palabras clave
- caffeine, blood pressure, caffeine tolerance, individual differences, sex differences, dose-response relationship
- MeSH
- saliva, humans, hypertension, caffeine, drug administration schedule, cross-over studies, double-blind method, blood pressure, vascular resistance, drug tolerance, adult, male
6 autores
- William R. Lovallo🇺🇸Kaleida Health; University of Oklahoma Health Sciences Center
- Michael F. Wilson🇺🇸Kaleida Health; University of Oklahoma Health Sciences Center
- Andrea S. Vincent🇺🇸Kaleida Health; University of Oklahoma Health Sciences Center
- Bong Hee Sung🇺🇸Kaleida Health; University of Oklahoma Health Sciences Center
- Barbara S. McKey🇺🇸Kaleida Health; University of Oklahoma Health Sciences Center
- Thomas L. Whitsett🇺🇸Kaleida Health; University of Oklahoma Health Sciences Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine acutely raises blood pressure (BP). The clinical significance of this effect depends on whether BP responses persist in persons who consume caffeine on a daily basis. Accordingly, the ability of caffeine to raise BP after 5 days of regular daily intake was tested in a randomized controlled trial. Individual differences in tolerance formation were then examined. Men (n=49) and women (n=48) completed a double-blind, crossover trial conducted over 4 weeks. During each week, subjects abstained for 5 days from dietary caffeine and instead used capsules totaling 0 mg, 300 mg, and 600 mg of caffeine per day in 3 divided doses. On day 6, in the laboratory, they used capsules with either 0 mg or 250 mg of caffeine at 9:00 am and 1:00 pm. Systolic/diastolic BP increases as a result of 250 mg of caffeine remained significant (P7.90, P <0.001). The sexes did not differ in degree of tolerance formation. Daily caffeine consumption failed to eliminate the BP response to repeated challenge doses of caffeine in half of the healthy adults who were tested. Caffeine may therefore cause persistent BP effects in persons who are regular consumers, even when daily intake is at moderately high levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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