Comparison of a high-carbohydrate and a high-monounsaturated fat, olive oil-rich diet on the susceptibility of LDL to oxidative modification in subjects with Type 2 diabetes mellitus
Rodríguez-Villar C, Pérez-Heras A, Mercadé I, Casals E, Ros E
Diabetic medicine : a journal of the British Diabetic Association · 53 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Comisión Interministerial de Ciencia y Tecnología
Según 1 financiador declarado.
Publicación
- Publicado
- 2004-01-30 · Diabet Med · vol. 21 · número 2 · págs. 142–149
- Editorial
- Wiley
- Citado
- 84 citas · más que el 96% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Palabras clave
- type 2 diabetes, olive oil, high-carbohydrate diet, LDL oxidation, copper-induced oxidation, conjugated dienes, VLDL cholesterol, VLDL triglycerides, lipoprotein profile, glycemic control, body weight, dietary fat composition, nutritional therapy
- MeSH
- humans, diabetes mellitus, type 2, dietary carbohydrates, fatty acids, monounsaturated, plant oils, cross-over studies, oxidation-reduction, aged, female, male, cholesterol, ldl, olive oil, diet, diabetic
5 autores
- Camino Rodrı́guez-Villar🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ana Pérez-Heras
- Imma Mercade🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Elena Casals🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Emilio Ros · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To compare the effects of a high-carbohydrate (CHO) diet and a high-monounsaturated fatty acid (MUFA) diet on LDL oxidative resistance in free-living individuals with Type 2 diabetes mellitus.
Methods
Twenty-two men and women out-patients with Type 2 diabetes, with mean age 61 years and in fair metabolic control (HbA1c<8.0%), were enrolled at a university hospital lipid clinic in a randomized, crossover feeding trial comparing two isocaloric diets for 6 weeks each: CHO (fat, 28% energy) and MUFA (fat, 40% energy) based on virgin olive oil. Outcome measurements were changes in LDL susceptibility to oxidation, body weight, glycaemic control, and lipoprotein profiles.
Results
Planned and observed diets were well matched. Participants preferred the MUFA diet over the CHO diet. The lag time of conjugated diene formation during Cu2+-induced LDL oxidation was similar after the CHO and MUFA diets (36.4 +/- 12.2 min and 36.0 +/- 13.7 min, respectively). Body weight, glycaemic control, total triglycerides, and total, LDL- and HDL-cholesterol levels also were similar after the two diets. Compared with the CHO diet, the MUFA diet lowered VLDL-cholesterol by 35% (P=0.023) and VLDL triglyceride by 16% (P=0.016).
Conclusions
Natural food-based high-CHO and high-MUFA diets have similar effects on LDL oxidative resistance and metabolic control in subjects with Type 2 diabetes. A MUFA diet is a good alternative to high-CHO diets for nutrition therapy of diabetes because it also has a beneficial effect on the lipid profile and superior patient acceptance.
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