Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study
Hirayama S, Hamazaki T, Terasawa K
European journal of clinical nutrition · 132 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-02-26 · Eur J Clin Nutr · vol. 58 · número 3 · págs. 467–473
- Editorial
- Springer Nature
- Citado
- 288 citas · más que el 100% de estudios similares · 21.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Attention Deficit Hyperactivity Disorder · Developmental and Educational Neuropsychology
- Palabras clave
- docosahexaenoic acid, fish oil supplementation, attention deficit hyperactivity disorder, children, ADHD symptoms, visual short-term memory, continuous performance, aggression, fatty acids, dietary intervention
- MeSH
- humans, docosahexaenoic acids, fish oils, placebos, treatment outcome, double-blind method, aggression, child behavior, memory, attention deficit disorder with hyperactivity, child, female, male
3 autores
- S Hirayama🇯🇵Kurashiki City College
- Tomohito Hamazaki🇯🇵 · autor de correspondenciaUniversity of Toyama
- Katsutoshi TERASAWA
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To investigate whether docosahexaenoic acid (DHA) supplementation was able to ameliorate attention-deficit/hyperactivity disorder(AD/HD) symptoms in AD/HD children.
Design and subjects
A placebo-controlled double-blind study with 40 AD/HD (including eight AD/HD-suspected) children of 6-12 y of age who were mostly without medication. Subjects of a DHA group (n=20) took active foods containing fish oil (fermented soybean milk, bread rolls and steamed bread; 3.6 g DHA/week from these foods) for 2 months, whereas those of a control group (n=20) took indistinguishable control foods without fish oil. The following items were measured at the start and end of the study: (1) attention deficit, hyperactivity and impulsivity (AD/HD-related symptoms according to DSM-IV criteria); (2) aggression assessed by both parents and teachers; (3) visual perception (finding symbols out of a table); (4) visual and auditory short-term memory; (5) development of visual-motor integration; (6) continuous performance; (7) impatience.
Results
Changes in tests 1, 2, 3, 5 and 7 over time did not significantly differ between the two groups. However, visual short-term memory and errors of commission (continuous performance) significantly improved in the control group compared with the changes over time in the DHA group (P=0.02 and 0.001, respectively). Recalculation without AD/HD-suspected subjects (n=4 each group) showed similar P-values with regard to both measures.
Conclusion
DHA supplementation did not improve AD/HD-related symptoms. Treatment of ADHD with fatty acids deserves further investigation, but careful attention should be paid as to which fatty acid(s) is used.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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