Transdermal nicotine maintenance attenuates the subjective and reinforcing effects of intravenous nicotine, but not cocaine or caffeine, in cigarette-smoking stimulant abusers
Sobel BF, Sigmon SC, Griffiths RR
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 26 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (DA 03890)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2004-01-19 · Neuropsychopharmacology · vol. 29 · número 5 · págs. 991–1003
- Editorial
- Springer Nature
- Citado
- 33 citas · más que el 80% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Smoking Behavior and Cessation · Nicotinic Acetylcholine Receptors Study · Substance Abuse Treatment and Outcomes
- Palabras clave
- nicotine patch, cocaine, caffeine, subjective effects, drug reinforcement, tolerance (pharmacology and immunology), stimulant abuse, cigarette smokers, cardiovascular effects, nicotine dependence
- MeSH
- humans, substance-related disorders, cocaine-related disorders, substance withdrawal syndrome, nicotine, caffeine, nicotinic agonists, central nervous system stimulants, administration, cutaneous, injections, intravenous, double-blind method, smoking cessation, blood pressure, adult, female, male, surveys and questionnaires
3 autores
- Bai-Fang X Sobel🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Stacey C. Sigmon🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Roland R. Griffiths🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of transdermal nicotine maintenance on the subjective, reinforcing, and cardiovascular effects of intravenously administered cocaine, caffeine, and nicotine were examined using double-blind procedures in nine volunteers with histories of using tobacco, caffeine, and cocaine. Each participant was exposed to two chronic drug maintenance phases (21 mg/day nicotine transdermal patch and placebo transdermal patch). Within each drug phase, the participant received intravenous injections of placebo, cocaine (15 and 30 mg/70 kg), caffeine (200 and 400 mg/70 kg), and nicotine (1.0 and 2.0 mg/70 kg) in mixed order across days. Subjective and cardiovascular data were collected before and repeatedly after drug or placebo injection. Reinforcing effects were also assessed after each injection with a Drug vs Money Multiple-Choice Form. Intravenous cocaine produced robust dose-related increases in subjective and reinforcing effects; these effects were not altered by nicotine maintenance. Intravenous caffeine produced elevations on several subjective ratings; nicotine maintenance did not affect these ratings. Under the placebo maintenance condition, intravenous nicotine produced robust dose-related subjective effects, with maximal increases similar to the high dose of cocaine; nicotine maintenance significantly decreased the subjective and reinforcing effects of intravenous nicotine. The results of the present study demonstrate that chronic nicotine maintenance produces tolerance to the effects of intravenous nicotine, but does not affect the subjective or reinforcing effects of cocaine or caffeine.
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