Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study
Larsen ER, Mosekilde L, Foldspang A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 225 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-03-01 · J Bone Miner Res · vol. 19 · número 3 · págs. 370–378
- Editorial
- Oxford University Press
- Citado
- 363 citas · más que el 100% de estudios similares · 16.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Balance, Gait, and Falls Prevention
- Palabras clave
- vitamin D supplementation, calcium supplementation, osteoporotic fractures, fracture prevention, community-dwelling older adults, vitamin D deficiency, calcium carbonate, home modification, acute hospitalization
- MeSH
- humans, osteoporosis, calcium, dietary, vitamin d, treatment outcome, hospitalization, mortality, program evaluation, time factors, aged, population, community health services, denmark, female, male, fractures, bone
3 autores
- Erik Roj Larsen🇩🇰 · autor de correspondenciaRegional Hospital Randers
- Leif Mosekilde🇩🇰Aarhus University Hospital
- Anders Foldspang🇩🇰Aarhus University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
This study of 9605 community-dwelling residents supports that vitamin D and calcium supplementation may prevent osteoporotic fractures in elderly in a northern European region known to be deficient in vitamin D, especially during winter periods.
Introduction
We evaluated the effect of two programs for the prevention of osteoporotic fractures leading to acute hospital admission in a population of elderly community-dwelling residents.
Materials and methods
This was a factorial, cluster-randomized, pragmatic, intervention study. We included 9605 community-dwelling residents aged 66+ years. We offered a prevention program of a daily supplement of 1000 mg of elemental calcium as calcium carbonate and 400 IU (10 microg) of vitamin D3 to a total of 4957 participants. Another program with evaluation and suggestions for the improvement of the domestic environment was offered to a total of 5063 participants. Both programs included revision of the resident's current pharmaceutical treatment. We achieved information on osteoporotic fractures in the study population from the Danish Hospital Registration Database. We defined osteoporotic fractures as low energy fractures of the proximal humerus, distal forearm, vertebral column, pelvis, cervical femur, and intertrochanteric femur.
Results
Active participation was 50.3% in the Calcium and Vitamin D Program and 46.4% in the Environmental and Health Program. We observed a 16% reduction in fracture incidence rate (relative risk [RR], 0.84; CI, 0.72-0.98; p < 0.025) among male and female residents offered the Calcium and Vitamin D Program (intention-to-prevent analysis).
Conclusions
This study supports that vitamin D and calcium supplementation may prevent osteoporotic fractures in community-dwelling elderly people in a northern European region known to be deficient in vitamin D, especially during winter periods.
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