Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study
Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 132 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-03-01 · J Bone Miner Res · vol. 19 · número 3 · págs. 419–428
- Editorial
- Oxford University Press
- Citado
- 211 citas · más que el 82% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 83 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Genetic Associations and Epidemiology
- Palabras clave
- vitamin D receptor gene, VDR BsmI polymorphism, bone mineral density, osteoporosis, genetic association, Hardy-Weinberg equilibrium, heterogeneity, multiple comparisons, recessive genetic model, bone mineral loss, women
- MeSH
- humans, osteoporosis, spinal injuries, femoral neck fractures, receptors, calcitriol, bone density, polymorphism, genetic, adult, aged, middle aged, female
5 autores
- Ammarin Thakkinstian🇹🇭 · autor de correspondenciaMahidol University; Ramathibodi Hospital
- Catherine Anne D’Este🇦🇺University of Newcastle Australia
- John A. Eisman🇦🇺Garvan Institute of Medical Research; St Vincent's Hospital Sydney
- Tuan V. Nguyen🇦🇺Garvan Institute of Medical Research; St Vincent's Hospital Sydney
- John Attia🇦🇺University of Newcastle Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
With the rise of molecular and genetic epidemiology, molecular association studies are increasingly common; however, meta-analysis of these studies has been a neglected area. This study performed a meta-analysis of the association of the vitamin D receptor (VDR) gene polymorphisms and BMD. We also highlight methodological issues that need to be resolved.
Introduction
With the rise of molecular and genetic epidemiology, molecular association studies are increasingly common; however, meta-analysis of these studies has been a neglected area. This study performed a meta-analysis of the association of vitamin D receptor (VDR) gene polymorphisms and BMD/osteoporosis and highlights methodological issues.
Materials and methods
Studies published from 1994 to 2001 were identified through Medline using PubMed software. The reference lists of the articles retrieved were also reviewed. Where eligible papers had insufficient information, we contacted authors by mail (up to three mailings) for additional information. Any observational study, which tested the association between VDR BsmI genotypes and either BMD or osteoporosis at the femoral neck or spine in adult women, was included in the review. Data were extracted independently by two reviewers (AT and JA) using a standardized data extraction form.
Results
The B allele was significantly associated with BMD at the spine; it seemed to follow a recessive model, with the BB genotype having lower BMD than Bb/bb genotypes at baseline, which led to greater bone mineral loss over time. Highlighted methodological lessons included the need to check Hardy-Weinberg equilibrium and the importance of exploring heterogeneity, pooling data in a manner that is sensitive to genetic models, and avoiding multiple comparisons.
Conclusion
With the proliferation of molecular association studies, there will be an increased need to quantify the magnitude of the risk associated with genetic polymorphisms. This will likely entail meta-analytic methods, and this meta-analysis highlights some of the methodological issues that will need to be resolved.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.