Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans
Kew S, Mesa MD, Tricon S, Buckley R, Minihane AM, Yaqoob P
The American journal of clinical nutrition · 163 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-04-01 · Am J Clin Nutr · vol. 79 · número 4 · págs. 674–681
- Editorial
- Elsevier BV
- Citado
- 240 citas · más que el 99% de estudios similares · 11.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, omega-3 fatty acids, immune function, T cell activation, CD69, neutrophils, monocytes, phagocytosis, cytokine production, adhesion molecules, immunomodulation
- MeSH
- neutrophils, humans, dietary fats, docosahexaenoic acids, eicosanoic acids, fish oils, cytokines, double-blind method, lymphocyte activation, phagocytosis, adult, aged, middle aged
6 autores
- Samantha Kew🇬🇧University of Reading
- María Dolores Mesa🇬🇧University of Reading
- Sabine Tricon🇬🇧University of Reading
- Richard A. Buckley🇬🇧University of Reading
- Anne Marie Minihane🇬🇧University of Reading
- Parveen Yaqoob🇬🇧 · autor de correspondenciaUniversity of Reading
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Supplementation of the diet with fish oil, which is rich in the long-chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is reported to decrease several markers of immune function. However, whether EPA, DHA, or a combination of the 2 exerts these immunomodulatory effects is unclear.
Objective
The objective of the study was to determine the effects of supplementation with an EPA-rich or DHA-rich oil on a range of immune outcomes representing key functions of human neutrophils, monocytes, and lymphocytes in healthy humans.
Design
In a placebo-controlled, double-blind, parallel study, 42 healthy subjects were randomly allocated to receive supplementation with either placebo (olive oil), EPA (4.7 g/d), or DHA (4.9 g/d) for 4 wk. Blood samples were taken before and after supplementation.
Results
The fatty acid composition of plasma phospholipids and neutrophils was dramatically altered by supplementation with EPA or DHA, and the effects of EPA differed notably from those of DHA. DHA supplementation decreased T lymphocyte activation, as assessed by expression of CD69, whereas EPA supplementation had no significant effect. Neither the EPA-rich oil nor the DHA-rich oil had any significant effect on monocyte or neutrophil phagocytosis or on cytokine production or adhesion molecule expression by peripheral blood mononuclear cells.
Conclusions
Supplementation with DHA, but not with EPA, suppresses T lymphocyte activation, as assessed by expression of CD69. EPA alone does not, therefore, influence CD69 expression. No other marker of immune function assessed in this study was significantly affected by either EPA or DHA.
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