Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
Stark KD, Holub BJ
The American journal of clinical nutrition · 132 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Heart and Stroke Foundation of Canada
- Gobierno
- Canadian Institutes of Health Research
Según 2 financiadores declarados.
Publicación
- Publicado
- 2004-05-01 · Am J Clin Nutr · vol. 79 · número 5 · págs. 765–773
- Editorial
- Elsevier BV
- Citado
- 177 citas · más que el 97% de estudios similares · 6.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Nutritional Studies and Diet
- Palabras clave
- docosahexaenoic acid supplementation, eicosapentaenoic acid, postmenopausal women, hormone replacement therapy, cardiovascular risk factors, serum triglycerides, HDL cholesterol, resting heart rate, omega-3 fatty acids, serum phospholipids
- MeSH
- humans, cardiovascular diseases, lipids, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, phospholipids, estrogen replacement therapy, analysis of variance, risk factors, cross-over studies, double-blind method, postmenopause, heart rate, dietary supplements, aged, middle aged, female, cholesterol, hdl
2 autores
- Ken D. Stark🇺🇸🇨🇦National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; University of Guelph
- Bruce John Holub🇺🇸🇨🇦 · autor de correspondenciaNational Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; University of Guelph
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary docosahexaenoic acid (DHA) has triacylglycerol-lowering potential and undergoes in vivo retroconversion to eicosapentaenoic acid (EPA) in humans. Hormone replacement therapy (HRT) influences circulating lipid concentrations and fatty acid metabolism. DHA supplementation has not been studied in postmenopausal women.
Objective
We studied the effects of supplementation with DHA (free of EPA) on the resulting elevation in EPA and on selected cardiovascular disease risk factors in postmenopausal women.
Design
Women receiving (n = 18) and not receiving (n = 14) HRT completed a randomized, double-blind, placebo-controlled crossover trial with a DHA supplement (2.8 g DHA/d). A washout period of > or =6 wk divided the two 28-d intervention periods. Fasting blood samples were collected for analysis.
Results
In all women, DHA supplementation was associated with significant changes (P < 0.05), including 20% lower serum triacylglycerol concentrations, 8% higher HDL-cholesterol concentrations, a 28% lower overall ratio of serum triacylglycerol to HDL cholesterol, and a 7% decrease in resting heart rate. DHA supplementation resulted in a 45% lower net increase (P = 0.02) in EPA and a 42% lower (P = 0.0028) estimated percentage retroconversion of DHA to EPA [DeltaEPA/(DeltaEPA + DeltaDHA) x 100] in women receiving than in those not receiving HRT.
Conclusion
With DHA supplementation, the accumulation of EPA in serum phospholipids is significantly attenuated in postmenopausal women receiving HRT compared with that in women not receiving HRT. DHA supplementation can also favorably influence selected cardiovascular disease risk factors in postmenopausal women.
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