Effect of Vitamin D on falls: a meta-analysis
Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY, Wong JB
JAMA · 774 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-04-27 · JAMA · vol. 291 · número 16 · pág. 1999
- Editorial
- American Medical Association
- Citado
- 1,322 citas · más que el 100% de estudios similares · 61.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D, falls, fall prevention, older adults, vitamin D supplementation, calcium supplementation, vitamin D3, 1,25-dihydroxyvitamin D3, vitamin D2, number needed to treat, subgroup analysis, vitamin D analogs, vitamin D deficiency, vitamin D toxicity, adverse effects, cost-effectiveness, quality of life
- MeSH
- humans, vitamin d, accidental falls, aged, randomized controlled trials as topic
7 autores
- Heike Annette Bischoff-Ferrari🇺🇸Brigham and Women's Hospital; Harvard University
- Bess Dawson‐Hughes
- Walter Churchill Willett
- Hannes B. Staehelin
- Marlet G. Bazemore
- Robert Y.L. Zee
- John B. Wong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Falls among elderly individuals occur frequently, increase with age, and lead to substantial morbidity and mortality. The role of vitamin D in preventing falls among elderly people has not been well established.
Objective
To assess the effectiveness of vitamin D in preventing an older person from falling.
Data sources
MEDLINE and the Cochrane Controlled Trials Register from January 1960 to February 2004, EMBASE from January 1991 to February 2004, clinical experts, bibliographies, and abstracts. Search terms included trial terms: randomized-controlled trial or controlled-clinical trial or random-allocation or double-blind method, or single-blind method or uncontrolled-trials with vitamin D terms: cholecalciferol or hydroxycholecalciferols or calcifediol or dihydroxycholecalciferols or calcitriol or vitamin D/aa[analogs & derivates] or ergocalciferol or vitamin D/bl[blood]; and with accidental falls or falls, and humans.
Study selection
We included only double-blind randomized, controlled trials (RCTs) of vitamin D in elderly populations (mean age, 60 years) that examined falls resulting from low trauma for which the method of fall ascertainment and definition of falls were defined explicitly. Studies including patients in unstable health states were excluded. Five of 38 identified studies were included in the primary analysis and 5 other studies were included in a sensitivity analysis.
Data extraction
Independent extraction by 3 authors using predefined data fields including study quality indicators.
Data synthesis
Based on 5 RCTs involving 1237 participants, vitamin D reduced the corrected odds ratio (OR) of falling by 22% (corrected OR, 0.78; 95% confidence interval [CI], 0.64-0.92) compared with patients receiving calcium or placebo. From the pooled risk difference, the number needed to treat (NNT) was 15 (95% CI, 8-53), or equivalently 15 patients would need to be treated with vitamin D to prevent 1 person from falling. The inclusion of 5 additional studies, involving 10 001 participants, in a sensitivity analysis resulted in a smaller but still significant effect size (corrected RR, 0.87; 95% CI, 0.80-0.96). Subgroup analyses suggested that the effect size was independent of calcium supplementation, type of vitamin D, duration of therapy, and sex, but reduced sample sizes made the results statistically nonsignificant for calcium supplementation, cholecalciferol, and among men.
Conclusions
Vitamin D supplementation appears to reduce the risk of falls among ambulatory or institutionalized older individuals with stable health by more than 20%. Further studies examining the effect of alternative types of vitamin D and their doses, the role of calcium supplementation, and effects in men should be considered.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.