Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopy
Barden AE, Mori TA, Dunstan JA, Taylor AL, Thornton CA, Croft KD, Beilin LJ, Prescott SL
Free radical research · 73 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of California Berkeley
- Gobierno
- National Health and Medical Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2004-02-09 · Free Radic Res · vol. 38 · número 3 · págs. 233–239
- Editorial
- Taylor & Francis
- Citado
- 97 citas · más que el 95% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Asthma and respiratory diseases
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, F2-isoprostanes, lipid peroxidation, oxidative stress, atopy, allergy prevention, antigen-presenting cells, HLA-DR expression, arachidonic acid, eicosapentaenoic acid, monocytes, olive oil, neonates
- MeSH
- antigen-presenting cells, erythrocyte membrane, fetal blood, humans, pregnancy complications, hypersensitivity, dietary fats, unsaturated, f2-isoprostanes, fish oils, plant oils, hla-dr antigens, cytokines, risk factors, lipid peroxidation, pregnancy, dietary supplements, adult, infant, newborn, female, olive oil
8 autores
- Anne E. Barden🇦🇺 · autor de correspondenciaRoyal Perth Hospital
- Trevor Anthony Mori🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Janet A. Dunstan
- Angela L. Taylor
- Catherine A. Thornton🇬🇧University of Southampton
- Kevin D. Croft🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Harry Perkins Institute of Medical Research
- Susan L. Prescott
Resumen
El texto original del estudio, en el idioma en que se publicó.
The anti-inflammatory properties of n-3 polyunsaturated fatty acids (n-3 PUFA) have suggested a potential role of these nutrients in dietary modification for prevention of allergic disease in early life. As oxidative stress is known to modify antigen presenting cell (APC) signalling and resulting immune responses, we examined the effects of maternal n-3 PUFA supplementation in pregnancy on markers of oxidative stress and APC function in neonates at high risk of allergy. Eighty-three pregnant atopic women were randomised to receive 4 g daily of either fish oil (n = 40) or olive oil (n = 43) capsules in a controlled trial from 20 weeks gestation until delivery. Plasma (cord blood) and urinary F2-isoprostanes were measured as markers of lipid peroxidation. Cord erythrocyte fatty acids and markers of APC function (HLA-DR expression and cytokine responses) were measured and related to levels of plasma F2-isoprostanes. Maternal fish oil supplementation lowered plasma (p < 0.0001) and urinary (p = 0.06) F2-isoprostanes. HLA-DR expression on APC was not different between the groups. In multiple regression analysis, 28.8% of the variance in plasma F2-isoprostanes was explained by positive relationships with erythrocyte arachidonic acid (AA) and monocyte HLA-DR expression and a negative relationship with erythrocyte eicosapentaenoic acid (EPA). This study shows that maternal supplementation with fish oil can attenuate neonatal lipid peroxidation. Clinical follow-up of these infants will help to determine if there are sustained effects on postnatal oxidative stress and expression of allergic disease.
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