Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy
Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, Biggar D
Neurology · 141 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-05-25 · Neurology · vol. 62 · número 10 · págs. 1771–1777
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 216 citas · más que el 97% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Nutrition and Health in Aging
- Palabras clave
- creatine monohydrate, Duchenne muscular dystrophy, dietary supplementation, muscle strength, grip strength, fat-free mass, body composition, corticosteroid therapy, oxidative DNA damage, bone degradation, N-telopeptide, 3-methylhistidine, creatine kinase, children
- MeSH
- muscle, skeletal, respiratory muscles, humans, muscular dystrophy, duchenne, creatine, creatinine, prednisone, pregnenediones, collagen, collagen type i, methylhistidines, peptides, deoxyguanosine, spirometry, organ size, hand strength, treatment outcome, drug therapy, combination, cross-over studies, body composition, adolescent, child, male, 8-hydroxy-2'-deoxyguanosine
7 autores
- Mark Andrew Tarnopolsky🇨🇦Western University; Hospital for Sick Children; McMaster University
- Douglas J. Mahoney🇨🇦Western University; Hospital for Sick Children; McMaster University
- Jiri Vajsar🇨🇦Western University; Hospital for Sick Children; McMaster University
- Christine Rodriguez🇨🇦Western University; Hospital for Sick Children; McMaster University
- Timothy J. Doherty🇨🇦Western University; Hospital for Sick Children; McMaster University
- Brian D. Roy🇨🇦Western University; Hospital for Sick Children; McMaster University
- D. Biggar🇨🇦Western University; Hospital for Sick Children; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine whether creatine monohydrate (CrM) supplementation increases strength and fat-free mass (FFM) in boys with Duchenne muscular dystrophy (DD).
Methods
Thirty boys with DD (50% were taking corticosteroids) completed a double-blind, randomized, cross-over trial with 4 months of CrM (about 0.10 g/kg/day), 6-week wash-out, and 4 months of placebo. Measurements were completed of pulmonary function, compound manual muscle and handgrip strength, functional tasks, activity of daily living, body composition, serum creatine kinase and gamma-glutamyl transferase activity and creatinine, urinary markers of myofibrillar protein breakdown (3-methylhistidine), DNA oxidative stress (8-hydroxy-2-deoxyguanosine [8-OH-2-dG]), and bone degradation (N-telopeptides).
Results
During the CrM treatment phase, there was an increase in handgrip strength in the dominant hand and FFM (p < 0.05), with a trend toward a loss of global muscle strength (p = 0.056) only for the placebo phase, with no improvements in functional tasks or activities of daily living. Corticosteroid use, but not CrM treatment, was associated with a lower 8-OH-2-dG/creatinine (p < 0.05), and CrM treatment was associated with a reduction in N-telopeptides (p < 0.05).
Conclusions
Four months of CrM supplementation led to increases in FFM and handgrip strength in the dominant hand and a reduction in a marker of bone breakdown and was well tolerated in children with DD.
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