Oral creatine supplements lower plasma homocysteine concentrations in humans
Korzun WJ
Clinical laboratory science : journal of the American Society for Medical Technology · 27 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-01-01 · Clin Lab Sci · vol. 17 · número 2 · págs. 102–6
- Editorial
- National Institutes of Health
- Citado
- 42 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Folate and B Vitamins Research · Metabolism and Genetic Disorders · Muscle metabolism and nutrition
- Palabras clave
- creatine supplementation, plasma homocysteine, hyperhomocysteinemia, multivitamins, folic acid, vitamin B12, creatinine excretion, healthy volunteers
- MeSH
- humans, cardiovascular diseases, creatine, homocysteine, administration, oral, dietary supplements, adult, middle aged, female, male
1 autor
- William J. Korzun🇺🇸 · autor de correspondenciaVirginia Commonwealth University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine if oral creatine supplements will lower the concentration of total plasma homocysteine (tHcy).
Setting/participants
Apparently healthy volunteers, at least 19 years old, were recruited from the University of South Alabama and surrounding community. DESIGN/INTERVENTION/MAIN OUTCOME: Participants took multi-vitamins daily for four weeks, then were randomly divided into two groups. The control group (C) continued to take multi-vitamins daily for an additional four weeks. The experimental group (EX) took multivitamins plus an amount of creatine each day equal to twice their daily creatinine excretion, for the additional four weeks. Total plasma homocysteine concentrations were measured in all participants at the beginning and at the end of the second four week interval.
Results
There were no statistically significant differences between the two groups in age, initial tHcy, serum folate, erythrocyte folate, serum vitamin B12, or creatinine excretion. After four weeks of creatine supplements, tHcy in EX changed by an average of -0.9 micromol/L (range: -1.8 to 0.0), compared to an average change of +0.2 micromol/L in C (range: -0.6 to 0.9) during the same four weeks. The difference in the changes in tHcy between the two groups was statistically significant (p < 0.01).
Conclusion
Creatine supplements may be an effective adjunct to vitamin supplements for lowering tHcy.
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