Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss
Petrie HJ, Chown SE, Belfie LM, Duncan AM, McLaren DH, Conquer JA, Graham TE
The American journal of clinical nutrition · 61 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Guelph
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
Según 2 financiadores declarados.
Publicación
- Publicado
- 2004-07-01 · Am J Clin Nutr · vol. 80 · número 1 · págs. 22–28
- Editorial
- Elsevier BV
- Citado
- 111 citas · más que el 96% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Diet, Metabolism, and Disease · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- caffeine, insulin resistance, insulin sensitivity index, oral glucose tolerance test, obesity, weight loss, proinsulin/insulin ratio, beta-cell insulin secretion, glucose homeostasis, sedentary men
- MeSH
- humans, insulin resistance, obesity, weight loss, lactic acid, xanthines, caffeine, insulin, proinsulin, c-peptide, blood glucose, central nervous system stimulants, glucose tolerance test, glucose clamp technique, exercise, diet, reducing, administration, oral, area under curve, double-blind method, adult, male
7 autores
- Heather Petrie🇨🇦University of Guelph
- Sara E Chown🇨🇦University of Guelph
- Laura M Belfie🇨🇦University of Guelph
- Alison M. Duncan🇨🇦University of Guelph
- Drew H. McLaren🇨🇦University of Guelph
- Julie A. Conquer🇨🇦University of Guelph
- Terry E. Graham🇨🇦 · autor de correspondenciaUniversity of Guelph
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caffeine ingestion decreases the insulin sensitivity index (ISI) for an oral-glucose-tolerance test (OGTT) and decreases insulin-induced glucose disposal in lean male subjects during a hyperinsulinemic clamp.
Objective
We examined the effects of caffeine ingestion on insulin and glucose homeostasis in obese men before and after a nutrition and exercise intervention.
Design
Nine sedentary, obese [body mass index (in kg/m(2)): 34.0 +/- 1.0] men who had refrained from exercise and caffeine ingestion for 48 h underwent 2 oral-glucose-tolerance tests (OGTTs). The subjects randomly received caffeine (5 mg/kg) or placebo 1 h before each OGTT. After a 12-wk nutrition and exercise intervention, during which time the subjects avoided dietary caffeine, the OGTTs were repeated.
Results
The intervention resulted in decreases (P < or = 0.05) in body weight (8.5 +/- 1.5 kg), percentage body fat (2.8 +/- 0.7%), and fasting glucose, insulin, and proinsulin concentrations and increases in the ISI for the placebo OGTT (P < or = 0.05). Caffeine caused a greater (P < or = 0.05) OGTT insulin response and a lower (P < or = 0.05) ISI both before and after weight loss. The proinsulin-insulin ratio indicated that neither weight loss nor caffeine affected the nature of the beta cell secretion of insulin.
Conclusions
A nutrition and exercise intervention improved, whereas caffeine ingestion impaired, insulin-glucose homeostasis in obese men. The results are consistent with previous findings that caffeine ingestion contributes to insulin resistance.
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