Financiado en parte por Fresenius-Kabi
Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients
Heller AR, Rössel T, Gottschlich B, Tiebel O, Menschikowski M, Litz RJ, Zimmermann T, Koch T
International journal of cancer · 118 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Fresenius-Kabi
Según 1 financiador declarado.
Publicación
- Publicado
- 2004-05-04 · Int J Cancer · vol. 111 · número 4 · págs. 611–616
- Editorial
- Wiley
- Citado
- 172 citas · más que el 98% de estudios similares · 8.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Clinical Nutrition and Gastroenterology · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, postoperative recovery, abdominal cancer surgery, total parenteral nutrition, soybean oil, liver function, pancreatic function, sepsis risk, IL-6/IL-10 ratio, ICU length of stay, weight loss
- MeSH
- liver, humans, sepsis, carcinoma, gastrointestinal neoplasms, pancreatic neoplasms, pancrelipase, fatty acids, omega-3, soybean oil, parenteral nutrition, total, postoperative care, risk factors, prospective studies, double-blind method, aged, middle aged, female, male
8 autores
- Axel Rüdiger Heller🇩🇪 · autor de correspondenciaUniversity Hospital Carl Gustav Carus; Technische Universität Dresden
- Thomas Rössel🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
- Birgit Gottschlich🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
- Oliver Tiebel🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
- Mario Menschikowski🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
- Rainer J. Litz🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
- Thomas Philipp Zimmermann🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
- Thea Koch🇩🇪University Hospital Carl Gustav Carus; Technische Universität Dresden
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiologic studies have indicated that high intake of saturated fat and/or animal fat increases the risk of colon and breast cancer. Omega-3 PUFAs in fish oil (FO) can inhibit the growth of human cancer cells in vitro and in vivo. These effects are related to the uptake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the cellular substrate pool and their competitive metabolism with arachidonic acid (AA) at the cyclooxygenase and 5-lipoxygenase levels. The metabolites of EPA and DHA have less inflammatory and immunosuppressant potency than the substances derived from AA. Based on previous experimental data, we hypothesized that FO supplementation after major abdominal cancer surgery would improve hepatic and pancreatic function. Ours was a prospective, randomized, double-blinded clinical trial on 44 patients undergoing elective major abdominal surgery, randomly assigned to receive total parenteral nutrition (TPN) supplemented with either soybean oil (SO 1.0 g/kg body weight daily, n = 20) for 5 days or a combination of FO and SO (FO 0.2 + SO 0.8 g/kg body weight daily, n = 24). Compared to pure SO supplementation in the postoperative period, FO significantly reduced ASAT [0.8 +/- 0.1 vs. 0.5 +/- 0.1 mmol/(l. sec)], ALAT [0.9 +/- 0.1 vs. 0.6 +/- 0.1 mmol/(l. sec)], bilirubin (16.1 +/- 5.3 vs. 6.9 +/- 0.6 mmol/l), LDH (7.7 +/- 0.4 vs. 6.7 +/- 0.4 mmol/(l. sec) and lipase (0.6 +/- 0.1 vs. 0.4 +/- 0.1 micromol/(l. sec) in the postoperative course. Moreover, patients with increased risk of sepsis (IL-6/IL-10 ratio >8) showed a tendency to shorter ICU stay (18 hr) under omega-3 PUFA treatment. Weight loss as encountered after the SO emulsion of 1.1 +/- 2.2 kg was absent in the FO group. After major abdominal tumor surgery, FO supplementation improved liver and pancreas function, which might have contributed to the faster recovery of patients.
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