The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus
Duffy EM, Meenagh GK, McMillan SA, Strain JJ, Hannigan BM, Bell AL
The Journal of rheumatology · 75 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-08-01 · J Rheumatol · vol. 31 · número 8 · págs. 1551–6
- Editorial
- National Institutes of Health
- Citado
- 114 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Systemic Lupus Erythematosus Research · Fatty Acid Research and Health · Natural Compounds in Disease Treatment
- Palabras clave
- systemic lupus erythematosus, omega-3 fish oil, dietary supplementation, copper supplementation, disease activity, eicosapentaenoic acid, dietary fatty acids, lupus management
- MeSH
- humans, lupus erythematosus, systemic, copper, fatty acids, omega-3, fish oils, drug therapy, combination, double-blind method, patient compliance, dietary supplements, adult, aged, middle aged, female, male
6 autores
- Emeir M. Duffy🇬🇧University of Ulster
- G Meenagh
- Stanley A. McMillan
- John Strain
- BERNADETTE MARY HANNIGAN
- Aubrey L Bell
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the effect of dietary supplementation with omega-3 fish oils with or without copper on disease activity in systemic lupus erythematosus (SLE). Fish oil supplementation has a beneficial effect on murine models of SLE, while exogenous copper can decrease the formation of lupus erythematosus cells in rats with a hydralazine-induced collagen disease.
Methods
A double blind, double placebo controlled factorial trial was performed on 52 patients with SLE. Patients were randomly assigned to 4 treatment groups. Physiological doses of omega-3 fish oils and copper readily obtainable by dietary means were used. One group received 3 g MaxEPA and 3 mg copper, another 3 g MaxEPA and placebo copper, another 3 mg copper and placebo fish oil, and the fourth group received both placebo capsules. Serial measurements of disease activity using the revised Systemic Lupus Activity Measure (SLAM-R) and peripheral blood samples for routine hematological, biochemical, and immunological indices were taken at baseline, 6, 12, and 24 weeks.
Results
There was a significant decline in SLAM-R score from 6.12 to 4.69 (p < 0.05) in those subjects taking fish oil compared to placebo. No significant effect on SLAM-R was observed in subjects taking copper. Laboratory variables were unaffected by either intervention.
Conclusion
In the management of SLE, dietary supplementation with fish oil may be beneficial in modifying symptomatic disease activity.
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