Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition
Greenway FL, De Jonge L, Blanchard D, Frisard M, Smith SR
Obesity research · 37 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-07-01 · Obes Res · vol. 12 · número 7 · págs. 1152–1157
- Editorial
- Wiley
- Citado
- 75 citas · más que el 90% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pharmacology and Obesity Treatment · Coffee research and impacts · Medicinal Plants and Bioactive Compounds
- Palabras clave
- Ephedra, caffeine, dietary supplements, weight loss, resting metabolic rate, body composition, fat loss, obesity, herbal supplement safety, pulse rate
- MeSH
- humans, ephedra, obesity, weight loss, caffeine, plant preparations, placebos, basal metabolism, diet, double-blind method, body composition, rest, adolescent, adult, aged, middle aged, female, male
5 autores
- Frank L. Greenway🇺🇸 · autor de correspondenciaPennington Biomedical Research Center
- Lilian de Jonge🇺🇸Pennington Biomedical Research Center
- D Blanchard🇺🇸Pennington Biomedical Research Center
- Madlyn I. Frisard🇺🇸Pennington Biomedical Research Center
- Steven R. Smith🇺🇸Pennington Biomedical Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To evaluate the effect of a dietary supplement containing herbal caffeine (70 mg/dose) and ephedra (24 mg/dose; C&E) on metabolic rate, weight loss, body composition, and safety parameters.
Research methods and procedures
In phase I, 12 healthy subjects with a BMI of 25 to 35 kg/m2 had resting metabolic rate (RMR) measured for 2 hours after ingesting C&E or a placebo on two occasions 1 week apart, followed by a 1-week washout before phase II. In phase II, these 12 and 28 additional subjects were randomized to a 12-week, double-blind trial comparing C&E (3 times/day) to placebo. In phase III, the C&E group was given open-label C&E for 3 months, and the placebo group was given C&E for 6 months.
Results
In phase I, C&E gave an average 8 +/- 0.1% (SE) rise in RMR over 2 hours compared with placebo (p < 0.01). In phase II, weight loss at 12 weeks was 3.5 +/- 0.6 kg with C&E compared with 0.8 +/- 0.5 kg with placebo (p < 0.02). The percentage fat lost, shown by DXA, was 7.9 +/- 2.9% with C&E and 1.9 +/- 1.1% with placebo (p < 0.05). Pulse decreased more in the placebo group that in the C&E group (p < 0.03). There were no differences in lipid levels or blood pressure. In phase III, there was a 6-month loss of 7.3% and 7.8% of initial body weight for the groups on placebo and C&E during phase II, respectively. There were no serious adverse events.
Discussion
C&E increased RMR significantly by 8% compared with placebo, promoted more weight and fat loss than placebo, and was well tolerated.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.