Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients
Visioli F, Caruso D, Grande S, Bosisio R, Villa M, Galli G, Sirtori C, Galli C
European journal of nutrition · 117 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-05-05 · Eur J Nutr · vol. 44 · número 2 · págs. 121–127
- Editorial
- Springer Science+Business Media
- Citado
- 220 citas · más que el 99% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Phytochemicals and Antioxidant Activities
- Palabras clave
- extra virgin olive oil, refined olive oil, vascular protection, cardioprotection, plasma antioxidant capacity, thromboxane B2, isoprostanes, oxidative stress, cardiovascular risk markers
- MeSH
- humans, cardiovascular diseases, phenols, lipids, dietary fats, unsaturated, isoprostanes, thromboxane b2, plant oils, risk factors, cross-over studies, oxidation-reduction, lipid peroxidation, adolescent, adult, aged, middle aged, female, male, hyperlipidemias, olive oil
8 autores
- Francesco Visioli🇮🇹 · autor de correspondenciaUniversity of Milan
- Donatella Caruso🇮🇹University of Milan
- Simona Grande🇮🇹University of Milan
- Raffaella Bosisio🇮🇹Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
- M. Villa
- G. Galli🇮🇹University of Milan
- Cesare Riccardo Sirtori🇮🇹University of Milan; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
- Corrado Lodovico Galli🇮🇹University of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In vitro, olive phenols exert potent antioxidant and enzyme-modulating activities.
Aim of the study
We comparatively evaluate, in mildly dyslipidemic patients, the vasoprotective potential of extra virgin olive oil.
Methods
22 patients were administered 40 mL/day of either extra-virgin, i. e. phenol rich, or refined, i. e. phenol poor, olive oils (EVOO or ROO, respectively, with nearly identical fatty acid composition), with a crossover design. Each treatment was carried out for seven weeks, with four weeks of washout in between. Plasma antioxidant capacity, serum thromboxane B2 (TXB2) formation, and urinary isoprostane excretion were evaluated as surrogate markers of cardioprotective potential and vascular function.
Results
No effects on plasma lipid/lipoprotein profile were observed. Conversely, EVOO consumption was associated with favorable effects on circulating markers. Namely, decreased serum TXB2 production and increased plasma antioxidant capacity were observed when EVOO was administered in both treatment arms. Neither treatment had any significant effect on isoprostane excretion.
Conclusions
EVOO consumption by mildly dyslipidemic patients is associated with favorable changes in circulating markers of cardiovascular condition. Based on current knowledge, these effects may be associated with cardioprotection.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.