CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans
Hofman MK, Weggemans RM, Zock PL, Schouten EG, Katan MB, Princen HM
The Journal of nutrition · 36 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
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- Marcadores de salud y funcionamiento
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- ZonMw
Según 1 financiador declarado.
Publicación
- Publicado
- 2004-09-01 · J Nutr · vol. 134 · número 9 · págs. 2200–2204
- Editorial
- Elsevier BV
- Citado
- 47 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition, Genetics, and Disease · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- CYP7A1, promoter polymorphism, dietary cholesterol, cafestol, plasma lipids, HDL cholesterol, total cholesterol, bile acid synthesis, saturated fat, trans fatty acids, interindividual variability, apolipoprotein E, normolipidemic subjects
- MeSH
- humans, diterpenes, cytosine, adenine, cholesterol, cholesterol 7-alpha-hydroxylase, lipids, cholesterol, dietary, dose-response relationship, drug, homozygote, polymorphism, genetic, alleles, female, male, cholesterol, hdl, controlled clinical trials as topic, promoter regions, genetic
6 autores
- M Hofman🇳🇱Netherlands Organisation for Applied Scientific Research; Wageningen University & Research
- Rianne M. Weggemans🇳🇱Unilever Research and Development Vlaardingen
- Peter L. Zock🇳🇱Wageningen University & Research
- Evert G. Schouten🇳🇱Wageningen University & Research
- Mira Katan🇳🇱Unilever Research and Development Vlaardingen; Wageningen University & Research
- Hans M. G. Princen🇳🇱 · autor de correspondenciaNetherlands Organisation for Applied Scientific Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
The response of plasma lipids to dietary cholesterol and fat varies among individuals. Variations in genes involved in cholesterol metabolism can be important in these interindividual differences. The rate-limiting enzyme in the conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase (CYP7A1). We investigated the effect of the A278-C promoter polymorphism in the CYP7A1 gene on responses of plasma lipids to an increased intake in dietary cholesterol (742 +/- 114 mg/d), cafestol (57 +/- 6 mg/d), saturated fat [change of 8-9 energy percent/d (en%/d)] and trans fat (change of 10-11 en%/d) in 496 normolipidemic subjects. These responses were measured in 26 previously published dietary trials. After adjustment for the apolipoprotein E genotype effect, AA-subjects consuming a cholesterol-rich diet had a smaller increase in plasma HDL cholesterol than CC-subjects (0.00 +/- 0.02 vs. 0.17 +/- 0.04 mmol/L; P < 0.001). Upon intake of cafestol, AA-subjects had a smaller increase in plasma total cholesterol than CC-subjects (0.69 +/- 0.10 vs. 1.01 +/- 0.10 mmol/L; P = 0.028). No effects of the polymorphism were found in the saturated and trans fat interventions. In conclusion, the CYP7A1 polymorphism has a small but significant effect on the increase in plasma HDL cholesterol and plasma total cholesterol after an increased intake of dietary cholesterol and cafestol, respectively.
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