Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty
Bairati I, Roy L, Meyer F
Circulation · 86 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- Fonds de Recherche du Québec - Santé
Según 2 financiadores declarados.
Publicación
- Publicado
- 1992-03-01 · Circulation · vol. 85 · número 3 · págs. 950–956
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 150 citas · más que el 100% de estudios similares · 20.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Coronary Interventions and Diagnostics · Antiplatelet Therapy and Cardiovascular Diseases
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, restenosis, percutaneous transluminal coronary angioplasty, eicosapentaenoic acid, docosahexaenoic acid, olive oil, coronary artery disease
- MeSH
- humans, coronary disease, recurrence, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, drug combinations, coronary angiography, risk factors, double-blind method, image processing, computer-assisted, middle aged, female, male, angioplasty, balloon, coronary
3 autores
- Isabelle Bairati🇨🇦Université Laval
- L Roy🇨🇦Université Laval
- François Meyer🇨🇦Université Laval
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous studies suggest that recurrence of coronary stenosis after percutaneous transluminal coronary angioplasty (PTCA) might be prevented with dietary supplements rich in omega-3 fatty acids. The purpose of the present study was to evaluate this hypothesis. In addition, the relation between usual dietary consumption of omega-3 fatty acids and restenosis was assessed.
Methods and results
A double-blind, randomized, controlled trial was conducted in which 205 patients undergoing a first PTCA received 15 capsules per day containing 1 g of either fish oil (2.7 g/day of eicosapentaenoic acid, 1.8 g/day of docosahexaenoic acid) or olive oil. The treatment was started 3 weeks before PTCA and continued for 6 months thereafter. Dietary intake was assessed by food frequency questionnaire. At 6 months after PTCA, patients underwent a control angiography. All angiographic lesions were measured by quantitative computer analysis. Four criteria were used to define restenosis. Restenosis occurred less often in the fish oil group (22.0-35.6% depending on the definition) than in the control group (40.0-53.3%). After controlling for other risk factors of restenosis, the association of fish oil supplementation with a lower frequency of restenosis was statistically significant (p = 0.03) for three of four definitions. After adjustment, a dietary intake of omega-3 fatty acids of more than 0.15 g/day was also associated with a lower frequency of restenosis (p less than or equal to 0.03).
Conclusions
This trial documented the protective effect of fish oil supplements on the recurrence of coronary stenosis 6 months after PTCA. The study results suggest that a dietary intervention could be useful in preventing restenosis.
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