Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects
Buckley R, Shewring B, Turner R, Yaqoob P, Minihane AM
The British journal of nutrition · 81 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-09-01 · Br J Nutr · vol. 92 · número 3 · págs. 477–483
- Editorial
- Cambridge University Press
- Citado
- 118 citas · más que el 98% de estudios similares · 8.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, fish oil supplementation, triglycerides, apolipoprotein E, apolipoprotein A-I, HDL cholesterol, HDL particle size, plasma phospholipids, docosapentaenoic acid, plasma lipid profile, cardiovascular risk
- MeSH
- humans, cholesterol, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, triglycerides, phospholipids, fish oils, apolipoprotein a-i, apolipoproteins c, apolipoproteins e, analysis of variance, double-blind method, dietary supplements, adult, aged, middle aged, female, male, cholesterol, ldl, apolipoprotein c-iii, cholesterol, hdl
5 autores
- Richard A. Buckley🇬🇧University of Reading
- Bethan Shewring🇬🇧University of Reading
- Rufus Turner🇬🇧University of Reading
- Parveen Yaqoob🇬🇧University of Reading
- Anne Marie Minihane🇬🇧 · autor de correspondenciaUniversity of Reading
Resumen
El texto original del estudio, en el idioma en que se publicó.
High doses of n-3 PUFA found in fish oils can reduce the circulating concentration of triacylglycerol (TG), which may contribute to the positive impact of these fatty acids on the risk of CVD. The present study aimed to establish the differential impact of EPA and docosahexaenoic (DHA) on plasma lipids and apo in adults. Forty-two normolipidaemic adult subjects completed a double-blind placebo controlled parallel study, receiving an EPA-rich oil (4.8 g EPA/d), DHA-rich oil (4.9 g DHA/d) or olive oil as control, for a period of 4 weeks. No effects of treatment on total cholesterol, LDL-cholesterol or HDL-cholesterol were evident. There was a significant 22 % reduction in TG level relative to the control value following the DHA treatment (P=0.032), with the 15 % decrease in the EPA group failing to reach significance (P=0.258). There were no significant inter-group differences in response to treatment for plasma apoA1, -C3 or -E levels, although a significant 15 % within-group increase in apoE was evident in the EPA (P=0.006) and DHA (P=0.003) groups. In addition, a within-group decrease in the apoA1:HDL-cholesterol ratio was observed in the DHA group, suggesting a positive impact of DHA on HDL particle size. The DHA intervention resulted in a significant increase in the proportion of EPA P=0.000 and DHA P=0.000 in plasma phospholipids, whilst significant increases in EPA P=0.000 and docosapentaenoic acid P=0.002, but not DHA P=0.193, were evident following EPA supplementation (P<0.05). Our present results indicate that DHA may be more efficacious than EPA in improving the plasma lipid profile.
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