Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion
Dullaart RP, Beusekamp BJ, Meijer S, Hoogenberg K, van Doormaal JJ, Sluiter WJ
Diabetologia · 24 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Marcadores de salud y funcionamiento
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1992-02-01 · Diabetologia · vol. 35 · número 2 · págs. 165–172
- Editorial
- Springer Science+Business Media
- Citado
- 28 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Chronic Kidney Disease and Diabetes · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- dietary fat, albuminuria, type 1 diabetes, diabetic nephropathy, polyunsaturated to saturated fatty acid ratio, glomerular filtration rate, atherogenic lipoproteins, LDL cholesterol, apolipoprotein B, HDL cholesterol, blood pressure, dietary intervention, urinary albumin excretion rate, serum lipids, long-term effects
- MeSH
- humans, albuminuria, diabetes mellitus, type 1, body weight, lipids, dietary fats, linoleic acids, linoleic acid, lipoproteins, glomerular filtration rate, regression analysis, prospective studies, blood pressure, renal circulation, adult, female, male, diet, diabetic
6 autores
- Robin P. F. Dullaart🇳🇱University Medical Center Groningen
- B. J. Beusekamp🇳🇱University Medical Center Groningen
- S. Meijer🇳🇱University Medical Center Groningen
- Klaas Hoogenberg🇳🇱University Medical Center Groningen
- Jaap J. van Doormaal🇳🇱University Medical Center Groningen
- Willem J Sluiter🇳🇱University Medical Center Groningen
Resumen
El texto original del estudio, en el idioma en que se publicó.
We conducted a 2-year prospective randomised study to investigate the effects of a linoleic-acid-enriched diet on albuminuria and lipid levels in Type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion (overnight urinary albumin excretion rate between 10 and 200 micrograms/min). Thirty-eight patients were randomly assigned to increase dietary polyunsaturated:saturated fatty acids ratio to 1.0 by replacement of saturated fat with linoleic-acid-rich products (n = 18, two dropouts, analysis was performed in n = 16) or to continue their usual diet (n = 20). The total fat and protein content of the diet was unaltered. Clinical characteristics, albuminuria, blood pressure, glomerular filtration rate, metabolic control and dietary composition were similar in the two groups at baseline. In the high linoleic acid diet group, linoleic intake rose from 7 +/- 4 to 11 +/- 2 energy % and polyunsaturated:saturated fatty acids ratio rose from 0.60 +/- 0.28 to 0.96 +/- 0.16 (p less than 0.001 compared to usual diet group). The median increase albuminuria was 58% (95% confidence interval, 13 to 109) during the first year (p less than 0.02) and 55% (95% confidence interval, 11 to 127) (p less than 0.01) during the second year. Glomerular filtration rate remained unaltered and filtration fraction tended to rise (p less than 0.05 compared to usual diet group). In the usual diet group, albuminuria did not significantly increased by 16% (95% confidence interval, -17 to 38) and glomerular filtration rate declined during the second year. Blood pressure tended to rise similarly in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
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