Vitamin D supplementation improves neuromuscular function in older people who fall
Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ
Age and ageing · 251 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-09-22 · Age Ageing · vol. 33 · número 6 · págs. 589–595
- Editorial
- Oxford University Press
- Citado
- 411 citas · más que el 98% de estudios similares · 9.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, neuromuscular function, falls in older adults, vitamin D insufficiency, vitamin D2, postural sway, choice reaction time, functional performance, balance, muscle strength, fracture risk, 25-hydroxyvitamin D, fall prevention, older women
- MeSH
- muscle, skeletal, humans, vitamin d, double-blind method, random allocation, psychomotor performance, accidental falls, dietary supplements, aged, aged, 80 and over, female, male, postural balance
1 autor
- Jugdeep K. Dhesi🇬🇧 · autor de correspondenciaGuy's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
vitamin D supplementation reduces the incidence of fractures in older adults. This may be partly mediated by effects of vitamin D on neuromuscular function.
Objective
to determine the effects of vitamin D supplementation on aspects of neuromuscular function known to be risk factors for falls and fractures.
Design
randomised, double-blind, placebo-controlled study.
Setting
falls clinic taking referrals from general practitioners and accident and emergency department.
Subjects
139 ambulatory subjects (>/=65 years) with a history of falls and 25-hydroxyvitamin D (25OHD) </=12 microg/l.
Intervention
patients were randomised to receive a single intramuscular injection of 600,000 i.u. ergocalciferol or placebo.
Outcome measures
assessments including biochemistry, postural sway, choice reaction time (CRT), aggregate functional performance time (AFPT), and quadriceps strength were carried out at baseline and 6 months post-intervention.
Results
baseline characteristics were comparable between both groups. 25OHD in the treatment group increased significantly at 6 months. AFPT deteriorated in the control group and improved in the intervention group, representing a significant difference between groups (+6.6 s versus -2.0 s, t = 2.80, P < 0.05). Similar changes were observed for CRT (-0.06 s versus +0.41 s, t = -2.52, P < 0.01) and postural sway (+0.0025 versus -0.0138, t = 2.35, P < 0.02). There was no significant difference in muscle strength change between groups (-10 N versus -2 N, t = -1.26, ns). A significant correlation between change in AFPT and change in 25OHD levels was observed (r = 0.19, P = 0.03). There was no significant difference in the number of falls (0.39 versus 0.24, t = 1.08, P = 0.28) or fallers (14 versus 11, P = 0.52) between two groups.
Conclusions
vitamin D supplementation, in fallers with vitamin D insufficiency, has a significant beneficial effect on functional performance, reaction time and balance, but not muscle strength. This suggests that vitamin D supplementation improves neuromuscular or neuroprotective function, which may in part explain the mechanism whereby vitamin D reduces falls and fractures.
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