The creatine content of Creatine Serum and the change in the plasma concentration with ingestion of a single dose
Harris RC, Almada AL, Harris DB, Dunnett M, Hespel P
Journal of sports sciences · 18 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- KU Leuven
Según 1 financiador declarado.
Publicación
- Publicado
- 2004-09-01 · J Sports Sci · vol. 22 · número 9 · págs. 851–857
- Editorial
- Taylor & Francis
- Citado
- 21 citas · más que el 61% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 16 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Nutrition and Health Studies
- Palabras clave
- creatine supplementation, creatine monohydrate, plasma creatine, creatinine, supplement quality control
- MeSH
- humans, nitrogen, creatine, creatinine, phosphocreatine, chromatography, high pressure liquid, administration, oral, dose-response relationship, drug, male
5 autores
- Roger C. Harris🇬🇧University of Chichester; Chichester College
- Anthony L. Almada
- D. Beorn Harris🇬🇧University of Chichester; Chichester College
- M. Dunnett🇬🇧University of London; Royal Veterinary College
- Peter Hespel🇧🇪KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Three samples of Creatine Serum ATP Advantage from Muscle Marketing USA, Inc. were assayed for creatine by two different techniques by four independent laboratories, and for creatinine by two different techniques by two laboratories. A further sample was assayed for phosphorylcreatine. Dry weight and total nitrogen were also analysed. Six male volunteers ingested in random order, over 3 weeks: (A) water; (B) 2.5 g creatine monohydrate (Cr.H2O) in solution; and (C) 5 ml Creatine Serum (reportedly containing an equivalent amount of Cr.H2O). Blood samples were collected before and up to 8 h after each treatment and plasma was analysed for creatine and creatinine. Eight-hour urine samples were analysed for creatine. Ingestion of 2.5 g creatine monohydrate in solution resulted in a significant increase in plasma creatine (from 59.1+/-11.8 micromol.l(-1) to 245.3+/-74.6 microM micromol.l(-1); mean+/-s) and urinary creatine excretion. No increase in plasma or urinary creatine or creatinine was found on ingestion of Creatine Serum or water. Analysis showed 5 ml of Creatine Serum to contain <10 mg Cr.H2O and approximately 90 mg creatinine. Phosphorylcreatine was not detectable and only a trace amount of phosphorous was present. Total nitrogen analysis ruled out significant amounts of other forms of creatine. We conclude that the trace amounts of creatine in the product would be too little to affect the muscle content even with multiple dosing.
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