Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections
Vlachopoulos C, Kosmopoulou F, Panagiotakos D, Ioakeimidis N, Alexopoulos N, Pitsavos C, Stefanadis C
Journal of the American College of Cardiology · 93 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-11-01 · J Am Coll Cardiol · vol. 44 · número 9 · págs. 1911–1917
- Editorial
- Elsevier BV
- Citado
- 135 citas · más que el 97% de estudios similares · 6.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Coffee research and impacts · Cardiovascular Function and Risk Factors
- Palabras clave
- cigarette smoking, caffeine, coffee consumption, aortic stiffness, arterial stiffness, wave reflection, pulse wave velocity, augmentation index, synergistic interaction, cardiovascular risk
- MeSH
- humans, aortic diseases, caffeine, central nervous system stimulants, blood flow velocity, stroke volume, cross-over studies, smoking, blood pressure, heart rate, myocardial contraction, drug synergism, pulsatile flow, adult, female, male, statistics as topic
7 autores
- Charalambos V. Vlachopoulos🇬🇷 · autor de correspondenciaHippocration General Hospital
- Foteini Kosmopoulou🇬🇷Hippocration General Hospital
- Demosthenes B. Panagiotakos🇬🇷Hippocration General Hospital
- N. Ioakeimidis🇬🇷Hippocration General Hospital
- Nikolaos A. Alexopoulos🇬🇷Hippocration General Hospital
- Christos E. Pitsavos🇬🇷Hippocration General Hospital
- Christodoulos Stefanadis🇬🇷Hippocration General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
We investigated the acute and chronic combined effect of cigarette smoking and caffeine intake on aortic stiffness and wave reflections.
Background
We have shown that smoking and caffeine separately increase arterial stiffness. Aortic stiffness and wave reflections are important determinants of the efficient performance of the cardiovascular system and prognosticators of cardiovascular risk.
Methods
The acute effects of smoking (one cigarette), caffeine (200 mg, equivalent to 2 cups of coffee), and smoking plus caffeine were studied in 24 healthy subjects according to a randomized, placebo- and sham procedure-controlled crossover design. The chronic effect of smoking and caffeine was studied in a population study that enrolled 160 healthy subjects.
Results
Acute study: there was a significant interaction between caffeine and smoking with regard to pulse-wave velocity (p < 0.01) and augmentation index (p < 0.05). When smoking followed caffeine intake, pulse-wave velocity and augmentation index increased further by 0.52 m/s and 13.4%, respectively, reaching a total of 0.85 m/s and 17.4%, 0.17 m/s and 9.2% in excess of the mere sum of caffeine effect (0.33 m/s and 4%) alone and smoking effect alone (0.35 m/s and 4.2%). Population study: there was a significant interaction of chronic coffee consumption and smoking regarding pulse-wave velocity (p < 0.05) and augmentation index (p = 0.001).
Conclusions
The present study shows, for the first time, that when smoking and caffeine intake are combined, they interact and exert a synergistic, unfavorable effect on aortic stiffness and wave reflections on both an acute and chronic basis.
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