Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state
Jellema A, Plat J, Mensink RP
European journal of clinical investigation · 103 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-11-01 · Eur J Clin Invest · vol. 34 · número 11 · págs. 766–773
- Editorial
- Wiley
- Citado
- 144 citas · más que el 97% de estudios similares · 7.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases · Edible Oils Quality and Analysis
- Palabras clave
- obesity, weight loss, fish oil, omega-3 fatty acids, low-grade inflammation, interleukin-6, C-reactive protein, plasminogen activator inhibitor-1, TNF-α, soluble TNF receptors, postprandial inflammation, dietary intervention
- MeSH
- humans, obesity, weight loss, docosahexaenoic acids, eicosapentaenoic acid, fish oils, tumor necrosis factor-alpha, c-reactive protein, plasminogen activator inhibitor 1, receptors, tumor necrosis factor, interleukin-6, capsules, fasting, cross-over studies, double-blind method, postprandial period, dietary supplements, male, biomarkers
3 autores
- Annemarie Jellema🇳🇱Maastricht University
- Jogchum Plat🇳🇱Maastricht University
- Ronald P. Mensink🇳🇱 · autor de correspondenciaMaastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In obese subjects, chronic low-grade inflammation contributes to an increased risk of metabolic abnormalities, which are reversed by weight loss. Sustained weight loss, however, is difficult to achieve and more insight into dietary approaches on anti-inflammatory responses in obese subjects is needed. In this respect, fish oil deserves attention.
Material and methods
Eleven obese men (BMI: 30-35 kg m(-2)) received daily fish oil (1.35 g n-3 fatty acids) or placebo capsules in random order for 6 weeks. Eight subjects continued with a weight reduction study that lasted 8 weeks. Mean weight loss was 9.4 kg. At the end of each experimental period a postprandial study was performed.
Results
Relative to fasting concentrations, interleukin-6 (IL-6) levels increased by 75% 2 h and by 118% 4 h after the meal (P < 0.001), when subjects consumed the control capsules. In contrast, C-reactive protein (C-RP) concentrations decreased slightly by 0.7% and 6.6% (P = 0.046), and those of plasminogen activator inhibitor-1 (PAI-1) antigen by, respectively, 26% and 53% (P < 0.001). Tumour necrosis factor-alpha (TNF-alpha; P = 0.330) and soluble TNF-receptor concentrations (sTNF-R55 and sTNF-R75; P = 0.451 and P = 0.108, respectively) did not change. Changes relative to fasting concentrations were not significantly affected by either fish oil or weight reduction. Absolute IL-6, C-RP, sTNF-R55, sTNF-R75, and PAI-1 antigen concentrations, however, were consistently lower after weight reduction, but not after fish oil consumption.
Conclusion
For slightly obese subjects a moderate intake of fish oil does not have the same favourable effects on markers for a low-grade inflammatory state as weight reduction.
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