Low level laser therapy in primary Raynaud's phenomenon--results of a placebo controlled, double blind intervention study
Hirschl M, Katzenschlager R, Francesconi C, Kundi M
The Journal of rheumatology · 34 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-12-01 · J Rheumatol · vol. 31 · número 12 · págs. 2408–12
- Editorial
- National Institutes of Health
- Citado
- 68 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 12 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Systemic Sclerosis and Related Diseases · Infrared Thermography in Medicine
- Palabras clave
- low-level laser therapy, primary Raynaud's phenomenon, vasospasm, infrared thermography, cold stimulation, predictors of treatment response, sham treatment, hyperemia
- MeSH
- humans, raynaud disease, pain measurement, treatment outcome, severity of illness index, analysis of variance, linear models, probability, risk assessment, follow-up studies, cross-over studies, double-blind method, reference values, female, male, low-level light therapy
4 autores
- Mirko Hirschl🇦🇹Hanusch Hospital
- Reinhold Katzenschlager
- Claudia Maria Francesconi
- Michael Kundi
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the efficacy of low level laser therapy in patients with primary Raynaud's phenomenon and predict the success of laser therapy by clinical characteristics.
Methods
Forty-eight patients were included in a randomized placebo controlled, double blind crossover study. Laser and sham therapy each were applied 5 days a week for 3 weeks. Clinical symptoms, exposure to triggers, and frequency and intensity of attacks were recorded in diaries. Results of infrared thermography before onset and at the end of both irradiation sequences were evaluated. Primary endpoint was the average intensity of attacks; secondary endpoints were average number of attacks and thermography results. Age, sex, duration of symptoms, age at onset of symptoms, evoking conditions other than cold, maximum temperature drop after cold provocation, and rewarming time after cold provocation were tested as potential predictors.
Results
Number of attacks and their intensity were significantly reduced during laser therapy compared to sham treatment. Thermographic parameters did not reach statistical significance. In a stepwise multiple regression analysis, evoking conditions other than cold (stress, wetness as additional triggers), rewarming time, and temperature decrease after cold provocation were significant predictors of therapeutic efficacy.
Conclusion
Low level laser therapy reduces frequency and severity of Raynaud attacks. The effect is most pronounced in patients with signs of decreased threshold for vasospasm and less effective in patients with delayed hyperemia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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