Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant
Hollis BW, Wagner CL
The American journal of clinical nutrition · 240 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of South Carolina
- Gobierno
- National Institutes of Health
Según 2 financiadores declarados.
Publicación
- Publicado
- 2004-12-01 · Am J Clin Nutr · vol. 80 · número 6 · págs. 1752S–1758S
- Editorial
- Elsevier BV
- Citado
- 430 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Breastfeeding Practices and Influences · Vitamin K Research Studies
- Palabras clave
- vitamin D supplementation, lactation, vitamin D2, vitamin D3, 25-hydroxyvitamin D, vitamin D deficiency, breast milk, infant vitamin D status, maternal vitamin D status, sun exposure, recommended dietary intake
- MeSH
- milk, human, humans, vitamin d deficiency, cholecalciferol, ergocalciferols, vitamin d, nutritional requirements, lactation, dose-response relationship, drug, nutrition policy, dietary supplements, adult, infant, infant, newborn, female, infant nutritional physiological phenomena, maternal nutritional physiological phenomena
2 autores
- Bruce W. Hollis🇺🇸 · autor de correspondenciaMedical University of South Carolina
- Carol L. Wagner🇺🇸Medical University of South Carolina
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scientific data pertaining to vitamin D supplementation during lactation are scarce. The daily recommended intake for vitamin D during lactation has been arbitrarily set at 400 IU/d (10 microg/d). This recommendation is irrelevant with respect to maintaining the nutritional vitamin D status of mothers and nursing infants, especially among darkly pigmented individuals. Our objective was to examine the effect of high-dose maternal vitamin D2 supplementation on the nutritional vitamin D status of mothers and nursing infants. Fully lactating women (n = 18) were enrolled at 1 mo after birth to 1 of 2 treatment arms, ie, 1600 IU vitamin D2 and 400 IU vitamin D3 (prenatal vitamin) or 3600 IU vitamin D2 and 400 IU vitamin D3, for a 3-mo study period. High-dose (1600 or 3600 IU/d) vitamin D2 supplementation for a period of 3 mo safely increased circulating 25-hydroxyvitamin D [25(OH)D] concentrations for both groups. The antirachitic activity of milk from mothers receiving 2000 IU/d vitamin D increased by 34.2 IU/L, on average, whereas the activity in the 4000 IU/d group increased by 94.2 IU/L. Nursing infant circulating 25(OH)D2 concentrations reflected maternal intake and the amount contained in the milk. With limited sun exposure, an intake of 400 IU/d vitamin D would not sustain circulating 25(OH)D concentrations and thus would supply only limited amounts of vitamin D to nursing infants in breast milk. A maternal intake of 2000 IU/d vitamin D would elevate circulating 25(OH)D concentrations for both mothers and nursing infants, albeit with limited capacity, especially with respect to nursing infants. A maternal intake of 4000 IU/d could achieve substantial progress toward improving both maternal and neonatal nutritional vitamin D status.
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