Caffeine has no effect on measures of cortical excitability
Orth M, Amann B, Ratnaraj N, Patsalos PN, Rothwell JC
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 33 citas
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Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-10-05 · Clin Neurophysiol · vol. 116 · número 2 · págs. 308–314
- Editorial
- Elsevier BV
- Citado
- 43 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 12 trabajos
- Acceso
- De pago
- Áreas de investigación
- Transcranial Magnetic Stimulation Studies · Coffee research and impacts · Neuroscience and Neuropharmacology Research
- Palabras clave
- caffeine, cortical excitability, motor cortex, short-interval intracortical inhibition, intracortical facilitation, cortical silent period, motor threshold, motor evoked potentials, decaffeinated coffee
- MeSH
- motor cortex, pyramidal tracts, neurons, humans, caffeine, central nervous system stimulants, double-blind method, electric stimulation, differential threshold, evoked potentials, motor, neural inhibition, magnetics, time factors, adult, female, male
5 autores
- Michael Orth🇬🇧 · autor de correspondenciaThe Royal Free Hospital; National Hospital for Neurology and Neurosurgery; UCL Queen Square Institute of Neurology; University College London
- Benedikt Lorenz Amann🇬🇧The Royal Free Hospital; National Hospital for Neurology and Neurosurgery; UCL Queen Square Institute of Neurology; University College London
- Neville Ratnaraj🇬🇧The Royal Free Hospital; National Hospital for Neurology and Neurosurgery; UCL Queen Square Institute of Neurology; University College London
- Philip N. Patsalos🇬🇧The Royal Free Hospital; National Hospital for Neurology and Neurosurgery; UCL Queen Square Institute of Neurology; University College London
- John C. Rothwell🇬🇧The Royal Free Hospital; National Hospital for Neurology and Neurosurgery; UCL Queen Square Institute of Neurology; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the effect of caffeine on motor thresholds, short interval intra-cortical inhibition (SICI), intra-cortical facilitation (ICF) and cortical silent periods in a placebo controlled double-blinded trial.
Methods
In eleven healthy non-smoking subjects the following parameters were measured using transcranial magnetic stimulation (TMS): motor thresholds (rest, RMT and active, AMT), SICI and ICF at different conditioning stimulus intensities (60, 70, 80, 90% AMT), cortical silent periods at 130, 150 and 175% AMT, and size of motor evoked potential at rest at 110, 125 and 150% RMT. Measurements were repeated after one cup of decaffeinated coffee. On another day, measurements were obtained before and after one cup of decaffeinated coffee that contained caffeine (3 mg/kg bodyweight). Caffeine concentrations were measured in serum before and after experiments. Experiments were conducted and data were evaluated blinded to the experimental condition.
Results
The results of repeated measurements of all parameters were similar comparing experiments on each day, or when comparing the caffeine arm of the study with the placebo arm.
Conclusions
Caffeine in a concentration similar to that in a strong cup of coffee does not have a major effect on TMS measures of motor cortex excitability.
Significance
In healthy controls, the design of TMS experiments that investigate the parameters assessed in this TMS study does not need to control for caffeine.
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