Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression
Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RA
Prostaglandins, leukotrienes, and essential fatty acids · 136 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Massey University
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-01-04 · Prostaglandins Leukot Essent Fatty Acids · vol. 72 · número 3 · págs. 211–218
- Editorial
- Elsevier BV
- Citado
- 207 citas · más que el 99% de estudios similares · 14.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Treatment of Major Depression · Tryptophan and brain disorders
- Palabras clave
- fish oil, depression, omega-3 polyunsaturated fatty acids, olive oil, adjunctive therapy, mood, dietary supplementation, community-based treatment, circulating fatty acids
- MeSH
- humans, fatty acids, omega-3, fish oils, plant oils, case-control studies, double-blind method, depression, affect, adolescent, adult, aged, middle aged, female, olive oil
5 autores
- Karen M. Silvers · autor de correspondencia
- Cheryl C. Woolley🇳🇿Massey University
- Frances C. Hamilton🇳🇿Massey University
- Peter Murray Watts🇳🇿Massey University
- Rosemary A. Watson
Resumen
El texto original del estudio, en el idioma en que se publicó.
Converging evidence suggests that omega-3 polyunsaturated fatty acids have aetiological importance in depression. To determine the effect of adding fish oil to existing therapy in participants who were being treated for depression in a community setting, 77 participants were randomly assigned to receive 8 g of either fish or olive oil per day in addition to their existing therapy. Fifty-nine (77%) participants completed 12 weeks of treatment. Dietary, biochemical and lifestyle factors were measured throughout the study. Mood was assessed using the Short Form Hamilton Depression Rating Scale (HDRS-SF) and the Beck Depression Inventory II. Sample size calculations were based on the HDRS-SF. Intention-to-treat and per protocol analyses were carried out using residual maximum likelihood. There was no evidence that fish oil improved mood when compared to the placebo oil, despite an increase in circulating omega-3 polyunsaturated fatty acids. However, mood improved significantly in both groups within the first 2 weeks of the study (P<0.001) and this improvement was sustained throughout. In conclusion, fish oil was no more effective than the control as an add-on therapy for depression in this setting.
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