Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence
Heatherley SV, Hayward RC, Seers HE, Rogers PJ
Psychopharmacology · 60 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-02-04 · Psychopharmacology (Berl) · vol. 178 · número 4 · págs. 461–470
- Editorial
- Springer Science+Business Media
- Citado
- 110 citas · más que el 96% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Blood Pressure and Hypertension Studies
- Palabras clave
- caffeine, caffeine abstinence, caffeine withdrawal, cognitive performance, psychomotor performance, mood, blood pressure, heart rate, hand steadiness, psychostimulant effects, timing of drug administration
- MeSH
- hand, humans, tremor, substance withdrawal syndrome, caffeine, central nervous system stimulants, administration, oral, drug administration schedule, double-blind method, affect, cognition, task performance and analysis, blood pressure, heart rate, time factors, temperance, adolescent, adult, female
4 autores
- Susan V. Heatherley🇬🇧University of Bristol
- Robert C. Hayward🇬🇧University of Bristol
- Helen E. Seers🇬🇧University of Bristol
- Peter J. Rogers🇬🇧 · autor de correspondenciaUniversity of Bristol
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Many studies have found that caffeine consumed after overnight caffeine abstinence improves cognitive performance and mood. Much less is known, however, about the effects of caffeine after shorter periods of caffeine abstinence.
Objectives
The aim of this study was to measure the effects on psychomotor and cognitive performance, mood, hand steadiness, blood pressure and heart rate of caffeine administration after periods of 4, 6, and 8 h of caffeine abstinence.
Methods
Participants (n = 49, 27 female) were moderate to moderate-high caffeine consumers (mean daily intake 370 mg/day). Following overnight caffeine abstinence, a 'pre-dose' of caffeine (1.2 mg/kg) was administered at 9 A.M, 11 A.M or 1 P.M. The participants started a baseline battery of measurements at 4 P.M.: before receiving caffeine (1.2 mg/kg) or placebo at 5 P.M.: They then performed the battery of tests again, starting at 5:30 P.M. This was a double-blind, placebo-controlled, randomised study.
Results
Performance and mood measurements confirmed a psychostimulant action of caffeine (versus placebo), but only after 8 h of caffeine abstinence. Caffeine also increased blood pressure after 8-h abstinence, whereas hand steadiness was decreased and perception of task demand was increased by caffeine after 4 h, but not after 6- and 8-h abstinence.
Conclusions
A second cup-of-coffee equivalent dose of caffeine only reliably affected cognitive performance and mood after an 8-h interval between doses, but not after shorter intervals (when caffeine had some adverse effects). These results show that, apart from caffeine consumption soon after waking, the daily pattern of caffeine intake of many typical caffeine consumers is not well explained by the short-term psychostimulant effects of caffeine.
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