Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure?
Karatzis E, Papaioannou TG, Aznaouridis K, Karatzi K, Stamatelopoulos K, Zampelas A, Papamichael C, Lekakis J, Mavrikakis M
International journal of cardiology · 66 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2004-04-03 · Int J Cardiol · vol. 98 · número 3 · págs. 425–430
- Editorial
- Elsevier BV
- Citado
- 116 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Coffee research and impacts · Cardiovascular Health and Disease Prevention · Blood Pressure and Hypertension Studies
- Palabras clave
- caffeine, coffee, decaffeinated coffee, central blood pressure, peripheral blood pressure, arterial wave reflection, augmentation index, applanation tonometry, pulse wave analysis, left ventricular afterload, hemodynamic response
- MeSH
- arteries, humans, caffeine, central nervous system stimulants, blood pressure monitoring, ambulatory, cross-over studies, double-blind method, blood pressure, ventricular function, left, adult, female, male, hemodynamics
9 autores
- Emmanouil N. Karatzis🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Theodore G. Papaioannou🇬🇷 · autor de correspondenciaNational and Kapodistrian University of Athens; Alexandra Hospital
- Konstantinos A. Aznaouridis🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Kalliopi Karatzi🇬🇷Harokopio University of Athens
- Kimon S. Stamatelopoulos🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Antonis Zampelas🇬🇷Harokopio University of Athens
- Christos M. Papamichael🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- John P Lekakis🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Myron Mavrikakis🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Data concerning blood pressure changes, acutely induced by caffeine consumption, are conflicting. Furthermore, limited data exist regarding central hemodynamic response to caffeine ingestion by healthy young subjects. We investigated the acute effect of coffee (80 mg of caffeine) and decaffeinated coffee on peripheral and central hemodynamics, as well as on wave reflections.
Subjects
For this purpose, 16 healthy volunteers (eight females and eight males, mean age 29+/-3.2 years) were investigated.
Methods
Repeated measurements were performed at baseline and 30, 60, 90 and 120 min after oral administration of each beverage in a double-blind crossover design. Aortic blood pressures, augmentation index (AI) and pressure (AP) and timing of reflected waves were evaluated by using applanation tonometry and pulse wave analysis.
Results
Regular coffee increased central systolic (SBP) and diastolic pressure (DBP) from 96.2+/-9.9 to 101.1+/-10.1 mmHg, p=0.011 and from 72.6+/-9.4 to 76.5+/-9.0 mmHg, p=0.027, respectively, but no change was observed following consumption of decaffeinated coffee. Peripheral systolic blood pressure did not change significantly after the administration of either coffee. Augmentation index increased significantly following regular coffee consumption. The change in AI was significantly higher following regular compared to decaffeinated coffee consumption as shown by analysis of variance (ANOVA) for repeated measures (p=0.001).
Conclusions
These caffeine effects reveal an unfavourable effect on wave reflections and therefore on left ventricular (LV) pulsatile afterload. It also revealed a significant acute effect of caffeine consumption on central hemodynamics which is not observed at peripheral pressures.
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