Caffeine effects on recovery sleep following 27 h total sleep deprivation
LaJambe CM, Kamimori GH, Belenky G, Balkin TJ
Aviation, space, and environmental medicine · 33 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-02-01 · Aviat Space Environ Med · vol. 76 · número 2 · págs. 108–13
- Editorial
- National Institutes of Health
- Citado
- 50 citas · más que el 91% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Coffee research and impacts · Sleep and Wakefulness Research
- Palabras clave
- caffeine, sleep deprivation, recovery sleep, caffeine dose-response, slow-wave sleep, sleep maintenance, sleep depth, psychomotor vigilance, alertness
- MeSH
- humans, sleep deprivation, caffeine, central nervous system stimulants, polysomnography, analysis of variance, cross-over studies, psychomotor performance, wakefulness, reaction time, sleep stages, dose-response relationship, drug, adolescent, adult, female, male
4 autores
- Cynthia M. LaJambe🇺🇸Walter Reed Army Institute of Research
- Gary H. Kamimori
- Gregory Lucas Belenky
- Thomas J. Balkin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Caffeine is widely used to reverse alertness and performance decrements. However, caffeine's effects on subsequent recovery sleep and post-recovery performance are not well documented and, therefore, were evaluated.
Methods
Six habitually low (LC: or = 400 mg x d(-1)) caffeine users completed a randomized crossover design. After 20 h of wakefulness, repeated doses of caffeine gum [0 (placebo) mg, 100 (low dose) mg, or 300 (high dose) mg] were administered at 03:00, 05:00, and 07:00. At 10:00 (27 h sleep deprivation) subjects slept for 8 h, followed by Psychomotor Vigilance Task (PVT) administration at 33 and 65 min post-awakening.
Results
Low dose caffeine increased stage 1 minutes only. However, high dose caffeine impaired sleep maintenance (reduced total sleep time/increased wake) and reduced sleep depth (increased stage 1 minutes/percentage and slow-wave sleep (SWS) latency, and reduced SWS minutes during the first third of the sleep period). With high dose caffeine, LC users had less SWS percentage as compared with HC users. The HC users had reduced stage 2 percentage with high dose caffeine as compared with placebo and low dose caffeine. Caffeine dose and habitual caffeine use did not influence post-recovery sleep PVT performance.
Discussion
Caffeine exerts mild deleterious dose-response effects on recovery sleep following total sleep deprivation, primarily early in the sleep period, with potential recovery from these effects after sufficient sleep as suggested by lack of post-recovery sleep performance deficits. Habitual caffeine use appears to minimally reduce caffeine effects.
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