Few adverse effects of long-term creatine supplementation in a placebo-controlled trial
Groeneveld GJ, Beijer C, Veldink JH, Kalmijn S, Wokke JH, van den Berg LH
International journal of sports medicine · 35 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-03-29 · Int J Sports Med · vol. 26 · número 4 · págs. 307–313
- Editorial
- Thieme Medical Publishers (Germany)
- Citado
- 64 citas · más que el 80% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Amyotrophic Lateral Sclerosis Research
- Palabras clave
- creatine monohydrate, long-term supplementation, adverse effects, amyotrophic lateral sclerosis, renal function, serum urea, urinary albumin, microalbuminuria, water retention, diarrhea, nausea, neurodegenerative diseases
- MeSH
- kidney, humans, amyotrophic lateral sclerosis, albuminuria, diarrhea, nausea, creatine, urea, creatinine, treatment outcome, administration, oral, double-blind method, time, dietary supplements, adolescent, adult, aged, middle aged, female, male
6 autores
- Geert Jan Groeneveld🇳🇱University Medical Center Utrecht
- Cornelis Beijer🇳🇱Rijnland Ziekenhuis
- Jan Herman Veldink🇳🇱University Medical Center Utrecht
- Sandra Kalmijn🇳🇱Utrecht University; University Medical Center Utrecht
- John H. J. Wokke🇳🇱University Medical Center Utrecht
- Leonard H. van den Berg🇳🇱University Medical Center Utrecht
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although oral creatine supplementation is very popular among athletes, no prospective placebo-controlled studies on the adverse effects of long-term supplementation have yet been conducted. We performed a double-blind, placebo-controlled trial of creatine monohydrate in patients with the neurodegenerative disease amyotrophic lateral sclerosis, because of the neuroprotective effects it was shown to have in animal experiments. The purpose of this paper is to compare the adverse effects, and to describe the effects on indirect markers of renal function of long-term creatine supplementation. 175 subjects (age = 57.7 +/- 11.1 y) were randomly assigned to receive creatine monohydrate 10 g daily or placebo during an average period of 310 days. After one month, two months and from then on every fourth month, adverse effects were scored using dichotomous questionnaires, plasma urea concentrations were measured, and urinary creatine and albumin concentrations were determined. No significant differences in the occurrence at any time of adverse effects due to creatine supplementation were found (23 % nausea in the creatine group, vs. 24 % in the placebo group, 19 % gastro-intestinal discomfort in the creatine group, vs. 18 % in the placebo group, 35 % diarrhoea in the creatine group, vs. 24 % in the placebo group). After two months of treatment, oedematous limbs were seen more often in subjects using creatine, probably due to water retention. Severe diarrhoea (n = 2) and severe nausea (n = 1) caused 3 subjects in the creatine group to stop intake of creatine, after which these adverse effects subsided. Long-term supplementation of creatine did not lead to an increase of plasma urea levels (5.69 +/- 1.47 before treatment vs. 5.26 +/- 1.44 at the end of treatment) or to a higher prevalence of micro-albuminuria (5.4 % before treatment vs. 1.8 % at the end of treatment).
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