The effect of alpha-linolenic acid and linoleic acid on the growth and development of formula-fed infants: a systematic review and meta-analysis of randomized controlled trials
Udell T, Gibson RA, Makrides M, PUFA Study Group
Lipids · 22 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-01-01 · Lipids · vol. 40 · número 1 · págs. 1–11
- Editorial
- Wiley
- Citado
- 50 citas · más que el 55% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Birth, Development, and Health
- Palabras clave
- alpha-linolenic acid, linoleic acid, infant formula, preterm infants, term infants, polyunsaturated fatty acids, infant growth, infant development, retinal function, erythrocyte phospholipids, plasma phospholipids
- MeSH
- retina, erythrocytes, humans, premature birth, alpha-linolenic acid, linoleic acid, phospholipids, body size, child development, time factors, infant formula, dietary supplements, infant, newborn
4 autores
- Tuesday Udell🇦🇺Flinders University
- Robert Alan Gibson🇦🇺Flinders Medical Centre
- Maria Makrides🇦🇺 · autor de correspondenciaWomen's and Children's Hospital; Women's & Children's Health Research Institute; Women's and Children's Health Network; The University of Adelaide
- PUFA Study Group
Resumen
El texto original del estudio, en el idioma en que se publicó.
This systematic review and meta-analysis aimed to evaluate the effect of modifying 18-carbon PUFA [18-C PUFA: alpha-linolenic acid (ALA, 18:3n-3) and linoleic acid (LA, 18:2n-6)] in the diets of term and preterm infants on DHA (22:6n-3) status, growth, and developmental outcomes. Only randomized controlled trials (RCT) involving formula-fed term and preterm infants, in which the 18-C PUFA composition of the formula was changed and growth or developmental outcomes were measured, were included. Differences were presented as control (standard formula) and treatment (18-C PUFA-supplemented formula). Primary analyses for term infants were 4 and 12 mon and for preterm infants 37-42 and 57 wk postmenstrual age. Five RCT involving term infants and three RCT involving preterm infants were included in the systematic review. Infants fed ALA-supplemented formula had significantly higher plasma and erythrocyte phospholipid DHA levels than control infants. There was no effect of ALA supplementation on the growth of preterm infants. In term infants, ALA supplementation was associated with increased weight and length at 12 mon, which was at least 4 mon after the end of dietary intervention. Developmental indices of term infants did not differ between groups. There was a transient improvement in the retinal function of preterm infants fed ALA-supplemented diets compared with controls. The findings suggest that ALA-supplemented diets improve the DHA status of infants. Further studies are needed to provide convincing evidence regarding the effects of ALA supplementation of formula on infant growth and development.
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