Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials
Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM
Journal of hypertension · 228 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-04-15 · J Hypertens · vol. 23 · número 5 · págs. 921–928
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 376 citas · más que el 87% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Palabras clave
- coffee, caffeine, blood pressure, hypertension, systolic blood pressure, diastolic blood pressure, heart rate, caffeine consumption
- MeSH
- humans, blood pressure, heart rate, coffee, adult, aged, middle aged, female, male
6 autores
- Marlies Noordzij🇳🇱Utrecht University; Wageningen University & Research
- Cuno S.P.M. Uiterwaal🇳🇱Utrecht University
- Lidia R. Arends🇳🇱Erasmus University Rotterdam
- Frans J. Kok🇳🇱Wageningen University & Research
- Diederick E. Grobbee🇳🇱Utrecht University
- Johanna Marianne Geleijnse🇳🇱 · autor de correspondenciaWageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Coffee is a widely consumed beverage and small health effects of substances in coffee may have large public health consequences. It has been suggested that caffeine in coffee increases the risk of hypertension. We performed a meta-analysis of randomized controlled trials of coffee or caffeine and blood pressure (BP).
Data identification
BP trials of coffee or caffeine published between January 1966 and January 2003 were identified through literature databases and manual search.
Study selection
A total of 16 studies with a randomized, controlled design and at least 7 days of intervention was selected, comprising 25 strata and 1010 subjects.
Data extraction
Two persons independently obtained data on sample size, type and duration of intervention, changes in BP and heart rate (HR), and subjects' characteristics for each trial. Meta-analysis was performed using a random-effects model.
Results
A significant rise of 2.04 mmHg [95% confidence interval (CI), 1.10-2.99] in systolic BP and 0.73 mmHg (95% CI, 0.14-1.31) in diastolic BP was found after pooling of coffee and caffeine trials. When coffee trials (n = 18, median intake: 725 ml/day) and caffeine trials (n = 7, median dose: 410 mg/day) were analysed separately, BP elevations appeared to be larger for caffeine [systolic: 4.16 mmHg (2.13-6.20); diastolic: 2.41 mmHg (0.98-3.84)] than for coffee [systolic: 1.22 mmHg (0.52-1.92) and diastolic: 0.49 mmHg (-0.06-1.04)]. Effects on HR were negligible.
Conclusions
Regular caffeine intake increases BP. When ingested through coffee, however, the blood pressure effect of caffeine is small.
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