Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care
Porthouse J, Cockayne S, King C, Saxon L, Steele E, Aspray T, Baverstock M, Birks Y, Dumville J, Francis R, Iglesias C, Puffer S, Sutcliffe A, Watt I, Torgerson DJ
BMJ (Clinical research ed.) · 306 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-04-28 · BMJ · vol. 330 · número 7498 · pág. 1003
- Citado
- 535 citas · más que el 100% de estudios similares · 63.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Hip and Femur Fractures
- Palabras clave
- calcium supplementation, vitamin D3, fracture prevention, hip fracture, osteoporosis, older women, fall prevention, dietary calcium, quality of life, medication adherence
- MeSH
- humans, hip fractures, cholecalciferol, vitamin d, treatment outcome, administration, oral, risk factors, pilot projects, aged, female
15 autores
- Jill Porthouse🇬🇧University of York
- Sarah Cockayne🇬🇧University of York
- Christine R. King🇬🇧Freeman Hospital
- Lucy Saxon
- Elizabeth Steele🇬🇧Freeman Hospital
- Terry Aspray🇬🇧Freeman Hospital
- Mike Baverstock
- Yvonne F. Birks🇬🇧University of York
- Jo C Dumville🇬🇧University of York
- Roger M. Francis🇬🇧Freeman Hospital
- Cynthia P Iglesias🇬🇧University of York
- Suezann Puffer🇬🇧University of York
- Anne Sutcliffe🇬🇧Freeman Hospital
- Ian Watt🇬🇧University of York
- David John Torgerson🇬🇧 · autor de correspondenciaUniversity of York
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess whether supplementation with calcium and cholecaliferol (vitamin D3) reduces the risk of fracture in women with one or more risk factors for fracture of the hip.
Design
Pragmatic open randomised controlled trial.
Setting
Practice nurse led clinics in primary care.
Participants
3314 women aged 70 and over with one or more risk factors for hip fracture: any previous fracture, low body weight (< 58 kg), smoker, family history of hip fracture, or fair or poor self reported health.
Intervention
Daily oral supplementation using 1000 mg calcium with 800 IU cholecaliferol and information leaflet on dietary calcium intake and prevention of falls, or leaflet only (control group).
Main outcome measures
Primary outcome measure was all clinical fractures and secondary outcome measures were adherence to treatment, falls, and quality of life (measured with the SF-12).
Results
69% of the women who completed the follow-up questionnaire at 24 months were still taking supplements (55% with inclusion of randomised participants known to be alive). After a median follow-up of 25 months (range 18 to 42 months), clinical fracture rates were lower than expected in both groups but did not significantly differ for all clinical fractures (odds ratio for fracture in supplemented group 1.01, 95% confidence interval 0.71 to 1.43). The odds ratio for hip fracture was 0.75 (0.31 to 1.78). The odds of a woman having a fall at six and 12 months was 0.99 and 0.98, respectively. Quality of life did not significantly differ between the groups.
Conclusion
We found no evidence that calcium and vitamin D supplementation reduces the risk of clinical fractures in women with one or more risk factors for hip fracture. Registration ISRCTN26118436, controlled trials registry.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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