Increased IGF mRNA in human skeletal muscle after creatine supplementation
Deldicque L, Louis M, Theisen D, Nielens H, Dehoux M, Thissen JP, Rennie MJ, Francaux M
Medicine and science in sports and exercise · 86 citas
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Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-05-01 · Med Sci Sports Exerc · vol. 37 · número 5 · págs. 731–736
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 140 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Growth Hormone and Insulin-like Growth Factors
- Palabras clave
- creatine supplementation, insulin-like growth factor I, insulin-like growth factor II, skeletal muscle, resistance training, muscle anabolism, p70S6K, 4E-BP1, mTOR signaling, mRNA expression, vastus lateralis, lean body mass
- MeSH
- muscle, skeletal, humans, creatine, ribosomal protein s6 kinases, 70-kda, insulin-like growth factor i, insulin-like growth factor ii, adaptor proteins, signal transducing, carrier proteins, cell cycle proteins, phosphoproteins, rna, messenger, biopsy, exercise, cross-over studies, double-blind method, phosphorylation, time factors, adult, male
8 autores
- Louise Deldicque🇧🇪UCLouvain; KU Leuven
- Magali Louis🇧🇪UCLouvain; KU Leuven
- Daniel Theisen🇧🇪UCLouvain; KU Leuven
- Henri Nielens🇧🇪UCLouvain; KU Leuven
- MISCHA L DEHOUX🇧🇪UCLouvain; KU Leuven
- Jean‐Paul Thissen🇧🇪UCLouvain; KU Leuven
- Michael J. Rennie🇬🇧University of Nottingham
- Marc Francaux🇧🇪UCLouvain; KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
We hypothesized that creatine supplementation would facilitate muscle anabolism by increasing the expression of growth factors and the phosphorylation of anabolic signaling molecules; we therefore tested the responses of mRNA for IGF-I and IGF-II and the phosphorylation state of components of anabolic signaling pathways p70(s6k) and 4E-BP1 to a bout of high-intensity resistance exercise after 5 d of creatine supplementation.
Methods
In a double-blind cross-over design, muscle biopsies were taken from the m. vastus lateralis at rest and 3 and 24 h postexercise in subjects who had taken creatine or placebo for 5 d (21 g x d(-1)). For the first 3 h postexercise, the subjects were fed with a drink containing maltodextrin (0.3 g x kg(-1) body weight x h(-1)) and protein (0.08 g x kg(-1) body weight x h(-1)).
Results
After creatine supplementation, resting muscle expressed more mRNA for IGF-I (+30%, P < 0.05) and IGF-II (+40%, P = 0.054). Exercise caused an increase by 3 h postexercise in IGF-I (+24%, P < 0.05) and IGF-II (+48%, P < 0.05) and by 24 h postexercise in IGF-I (+29%, P < 0.05), but this effect was not potentiated by creatine supplementation. The phosphorylation states of p70(s6k) and 4E-BP1 were not affected by creatine at rest; phosphorylation of both increased (150-400%, P < 0.05) to similar levels under placebo and creatine conditions at 3 h postexercise plus feeding. However, the phosphorylation state of 4E-BP1 was higher in the creatine versus placebo condition at 24 h postexercise.
Conclusion
The increase in lean body mass often reported after creatine supplementation could be mediated by signaling pathway(s) involving IGF and 4E-BP1.
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