Placebo-controlled study of intravenous magnesium supplementation during large-volume leukapheresis in healthy allogeneic donors
Haddad S, Leitman SF, Wesley RA, Cecco S, Yau YY, Starling J, Rehak NN, Bolan CD
Transfusion · 17 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-05-31 · Transfusion · vol. 45 · número 6 · págs. 934–944
- Editorial
- Wiley
- Citado
- 21 citas · más que el 79% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Blood transfusion and management · Hematopoietic Stem Cell Transplantation
- Palabras clave
- ionized magnesium, citrate anticoagulant, citrate toxicity, parathyroid hormone response, hypomagnesemia, adverse effects
- MeSH
- humans, paresthesia, potassium, calcium, magnesium, citric acid, creatinine, parathyroid hormone, anticoagulants, placebos, solutions, leukapheresis, transplantation, homologous, infusions, intravenous, prospective studies, double-blind method, blood volume, hydrogen-ion concentration, time factors, adult, aged, middle aged, blood donors, female, male
8 autores
- Salim Haddad🇺🇸 · autor de correspondenciaNational Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- Susan F. Leitman🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- ROBERT A. WESLEY🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- Stacey A. Cecco🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- Yu Ying Yau🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- Judith M. Starling🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- Nadja N. Rehak🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
- Charles D. Bolan🇺🇸National Institutes of Health; Office of the Director; National Institutes of Health Clinical Center; Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Marked decreases in ionized magnesium (iMg) levels occur during large-volume leukapheresis (LVL); however, the effect of intravenous (IV) magnesium supplementation in this setting has not been carefully studied.
Study design and methods
Thirty healthy allogeneic peripheral blood progenitor cell donors receiving citrate anticoagulant with IV calcium prophylaxis were randomized to receive either IV magnesium (0.2 mg Mg per mL acid citrate dextrose-A) or placebo during LVL, with a double-blind design.
Results
Thirty subjects underwent 75 LVL pro- cedures, 37 with magnesium and 38 with placebo. Group characteristics were similar for sex, weight, citrate infusion rate (1.36 mg/kg/min vs. 1.37 mg/kg/min), and volume processed (16 L vs. 17 L). Serum iMg levels remained within the reference range with magnesium supplementation, but decreased 39+/-11 percent below baseline (p<10(-10)) after placebo, with greater decreases after consecutive procedures. Subjects receiving magnesium had more vigorous parathyroid hormone responses and higher glucose levels and also tended to have higher serum potassium and ionized calcium levels. Mild paresthesias, coldness, and nausea occurred in 28, 20, and 7 percent of donors, respectively, with no significant differences between groups. Severe symptoms (chest tightness) occurred in only one subject receiving placebo.
Conclusion
IV magnesium supplementation exerts a significant impact on serum magnesium levels, but does not reduce the frequency or severity of the relatively mild citrate-related effects observed in LVL performed with continuous IV calcium prophylaxis.
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