Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype
Wilkinson P, Leach C, Ah-Sing EE, Hussain N, Miller GJ, Millward DJ, Griffin BA
Atherosclerosis · 75 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Food Standards Agency
- Universidad u hospital
- University of Surrey
Según 2 financiadores declarados.
Publicación
- Publicado
- 2005-02-05 · Atherosclerosis · vol. 181 · número 1 · págs. 115–124
- Editorial
- Elsevier BV
- Citado
- 121 citas · más que el 98% de estudios similares · 9.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- alpha-linolenic acid, fish oil, linseed oil, sunflower oil, atherogenic lipoprotein phenotype, cardiovascular risk markers, erythrocyte membrane fatty acids, docosahexaenoic acid, eicosapentaenoic acid, serum cholesterol, HDL cholesterol, triglycerides, small dense LDL, n-6/n-3 PUFA ratio, dietary intervention
- MeSH
- erythrocyte membrane, humans, cardiovascular diseases, arteriosclerosis, lipids, alpha-linolenic acid, docosahexaenoic acids, eicosapentaenoic acid, linseed oil, fatty acids, fatty acids, unsaturated, lipoproteins, lipoproteins, hdl, lipoproteins, ldl, phospholipids, fish oils, plant oils, diet, risk factors, phenotype, adult, middle aged, male, biomarkers, sunflower oil
7 autores
- Paul M.H. Wilkinson🇬🇧University of Surrey
- Clare Leach🇬🇧University of Surrey
- Eric Ah-Sing🇬🇧University of Surrey
- Nahed Hussain🇬🇧University of Surrey
- George J. Miller
- D. J. Millward🇬🇧University of Surrey
- Bruce Arthur Griffin🇬🇧 · autor de correspondenciaUniversity of Surrey
Resumen
El texto original del estudio, en el idioma en que se publicó.
We tested the hypothesis that dietary alpha-linolenic acid (ALA) can exert effects on markers of cardiovascular risk similar to that produced by its longer chain counterparts in fish-oil. A dietary intervention study was undertaken to examine the effects of an ALA-enriched diet in 57 men expressing an atherogenic lipoprotein phenotype (ALP). Subjects were randomly assigned to one of three diets enriched either with flaxseed oil (FXO: high ALA, n = 21), sunflower oil (SO: high linoleic acid, n = 17), or SO with fish-oil (SOF n = 19) for 12 weeks, resulting in dietary intake ratios of n-6:n-3 PUFA of 0.5, 27.9 and 5.2, respectively. The relative abundance of ALA and EPA in erythrocyte membranes increased on the FXO diet (p < 0.001), whereas both EPA and DHA increased after fish-oil (p < 0.001). There were significant decreases in total plasma cholesterol within (FXO -12.3%, p = 0.001; SOF -7.6%, p = 0.014; SO -7.3%, p = 0.033) and between diets (p = 0.019), and decreases within diets after 12 weeks for HDL cholesterol on flaxseed oil (FXO -10%, p=0.009), plasma TG (-23%, p < 0.001) and small, dense LDL (-22% p = 0.003) in fish-oil. Membrane DHA levels were inversely associated with the changes in plasma TG ( p= 0.001) and small, dense LDL (p<0.05) after fish-oil. In conclusion, fish-oil produced predictable changes in plasma lipids and small, dense LDL (sdLDL) that were not reproduced by the ALA-enriched diet. Membrane DHA levels appeared to be an important determinant of these fish-oil-induced effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.