Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease
Fuld JP, Kilduff LP, Neder JA, Pitsiladis Y, Lean ME, Ward SA, Cotton MM
Thorax · 85 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Universidad u hospital
- University of Glasgow
Según 2 financiadores declarados.
Publicación
- Publicado
- 2005-07-01 · Thorax · vol. 60 · número 7 · págs. 531–537
- Editorial
- BMJ
- Citado
- 145 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Chronic Obstructive Pulmonary Disease (COPD) Research · Nutrition and Health in Aging
- Palabras clave
- creatine supplementation, chronic obstructive pulmonary disease, pulmonary rehabilitation, fat-free mass, muscle strength, muscular endurance, exercise performance, skeletal muscle atrophy, body composition, St George's Respiratory Questionnaire, dietary supplementation, creatine monohydrate, shuttle walk test, cycle ergometry, quadriceps strength, health status, mortality risk factors, sarcopenia prevention
- MeSH
- humans, pulmonary disease, chronic obstructive, cachexia, creatine, vital capacity, forced expiratory volume, administration, oral, double-blind method, exercise tolerance, quality of life, dietary supplements, middle aged
1 autor
- Jonathan P. Fuld🇬🇧 · autor de correspondenciaRoyal Papworth Hospital; Papworth Hospital NHS Foundation Trust; University of Glasgow
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Skeletal muscle wasting and dysfunction are strong independent predictors of mortality in patients with chronic obstructive pulmonary disease (COPD). Creatine nutritional supplementation produces increased muscle mass and exercise performance in health. A controlled study was performed to look for similar effects in 38 patients with COPD.
Methods
Thirty eight patients with COPD (mean (SD) forced expiratory volume in 1 second (FEV(1)) 46 (15)% predicted) were randomised to receive placebo (glucose polymer 40.7 g) or creatine (creatine monohydrate 5.7 g, glucose 35 g) supplements in a double blind trial. After 2 weeks loading (one dose three times daily), patients participated in an outpatient pulmonary rehabilitation programme combined with maintenance (once daily) supplementation. Pulmonary function, body composition, and exercise performance (peripheral muscle strength and endurance, shuttle walking, cycle ergometry) took place at baseline (n = 38), post loading (n = 36), and post rehabilitation (n = 25).
Results
No difference was found in whole body exercise performance between the groups: for example, incremental shuttle walk distance mean -23.1 m (95% CI -71.7 to 25.5) post loading and -21.5 m (95% CI -90.6 to 47.7) post rehabilitation. Creatine increased fat-free mass by 1.09 kg (95% CI 0.43 to 1.74) post loading and 1.62 kg (95% CI 0.47 to 2.77) post rehabilitation. Peripheral muscle performance improved: knee extensor strength 4.2 N.m (95% CI 1.4 to 7.1) and endurance 411.1 J (95% CI 129.9 to 692.4) post loading, knee extensor strength 7.3 N.m (95% CI 0.69 to 13.92) and endurance 854.3 J (95% CI 131.3 to 1577.4) post rehabilitation. Creatine improved health status between baseline and post rehabilitation (St George's Respiratory Questionnaire total score -7.7 (95% CI -14.9 to -0.5)).
Conclusions
Creatine supplementation led to increases in fat-free mass, peripheral muscle strength and endurance, health status, but not exercise capacity. Creatine may constitute a new ergogenic treatment in COPD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.