Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants
Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Rozelle JC, Turcich MR, Llorente AM, Anderson RE, Heird WC
The American journal of clinical nutrition · 157 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-07-01 · Am J Clin Nutr · vol. 82 · número 1 · págs. 125–132
- Editorial
- Elsevier BV
- Citado
- 278 citas · más que el 99% de estudios similares · 14.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Breastfeeding Practices and Influences
- Palabras clave
- docosahexaenoic acid, maternal DHA supplementation, breastfeeding, infant brain development, visual function, breast milk fatty acid composition, algal oil, psychomotor development, term infants
- MeSH
- milk, human, humans, docosahexaenoic acids, phospholipids, double-blind method, child development, psychomotor performance, breast feeding, evoked potentials, visual, visual acuity, adult, child, preschool, infant, female, male
10 autores
- Craig L. Jensen🇺🇸 · autor de correspondenciaAgricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Robert G. Voigt🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Thomas C. Prager🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Yali Zou🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- J. Kennard Fraley🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Judith C Rozelle🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Marie R. Turcich🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Antolin M. Llorente🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- Robert E. Anderson🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
- William C. Heird🇺🇸Agricultural Research Service; Baylor College of Medicine; Robert Cizik Eye Clinic; Dean McGee Eye Institute; Children's Nutrition Research Center at Baylor College of Medicine; University of Oklahoma Health Sciences Center; The University of Texas Health Science Center at Houston
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Normal brain and visual development is thought to require exogenous docosahexaenoic acid (DHA; 22:6n-3) intake, but the amount needed is debatable. Because the supplementation of breastfeeding mothers with DHA increases the DHA content of their infants' plasma lipids, we hypothesized that it might also improve brain or visual function in the infants.
Objective
The objective was to determine the effect of DHA supplementation of breastfeeding mothers on neurodevelopmental status and visual function in the recipient infant.
Design
Breastfeeding women received capsules containing either a high-DHA algal oil ( approximately 200 mg DHA/d) or a vegetable oil (no DHA) for 4 mo after delivery. Outcome variables included the fatty acid pattern of maternal plasma phospholipid and milk lipids 4 mo postpartum, the fatty acid pattern of plasma phospholipids and visual function in infants at 4 and 8 mo of age, and neurodevelopmental indexes of the infants at 12 and 30 mo of age.
Results
Milk lipid and infant plasma phospholipid DHA contents of the supplemented and control groups were approximately 75% and approximately 35% higher, respectively, at 4 mo postpartum. However, neither the neurodevelopmental indexes of the infants at 12 mo of age nor the visual function at 4 or 8 mo of age differed significantly between groups. In contrast, the Bayley Psychomotor Development Index, but not the Mental Development Index, of the supplemented group was higher (P < 0.01) at 30 mo of age.
Conclusion
DHA supplementation of breastfeeding mothers results in higher infant plasma phospholipid DHA contents during supplementation and a higher Bayley Psychomotor Development Index at 30 mo of age but results in no other advantages either at or before this age.
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