Financiado en parte por Meat and Livestock Australia
A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet
Mamo JC, James AP, Soares MJ, Griffiths DG, Purcell K, Schwenke JL
European journal of clinical nutrition · 24 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Meat and Livestock Australia
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-07-13 · Eur J Clin Nutr · vol. 59 · número 10 · págs. 1142–1148
- Editorial
- Springer Nature
- Citado
- 30 citas · más que el 82% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipid metabolism and disorders · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- low-protein diet, high-protein diet, red meat, chylomicrons, postprandial lipemia, hypertriglyceridemia, apolipoprotein B-48, triglyceride kinetics, dietary protein, insulin sensitivity, dyslipidemia
- MeSH
- humans, cholesterol, dietary carbohydrates, blood glucose, dietary fats, triglycerides, chylomicrons, apolipoproteins b, dietary proteins, diet, protein-restricted, area under curve, postprandial period, meat, adult, middle aged, female, male, lipid metabolism, hyperlipidemias
6 autores
- John C.L. Mamo🇦🇺 · autor de correspondenciaCurtin University
- Anthony Paul James🇦🇺Curtin University
- Mário J. Soares🇦🇺Curtin University
- Denise Griffiths🇦🇺Curtin University
- Katrina Purcell🇦🇺Curtin University
- J L Schwenke🇦🇺Curtin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate whether altering energy intake as red meat protein or carbohydrate modifies chylomicron homeostasis and postprandial lipaemia.
Design
Randomized single-blind dietary intervention trial.
Setting
School of Public Health, Division of Health Science, Curtin University, Perth, Western Australia.
Subjects
A total of 20 moderately hypertriglyceridaemic but otherwise healthy subjects were recruited and completed the study.
Intervention
Participants consumed an isocaloric weight maintenance diet low in protein (14, 53 and 30% of energy as protein, carbohydrate and fat, respectively) or high in protein (25, 35 and 30% energy as protein, carbohydrate and fat) for a period of 6 weeks. Fasting plasma lipids and postprandial lipoprotein studies (triglyceride and apolipoprotein B48) following an oral fat challenge were carried out at the start and conclusion of the dietary intervention period.
Results
Consumption of the low- or high-protein diet had no significant effect on fasting plasma or postprandial lipaemia, the latter determined as the incremental area under the triglyceride curve following a fat challenge. However, subjects who consumed a low-protein diet for 6 weeks had a substantially exaggerated postprandial chylomicron response, indicated as the area under the apo B48 curve following a fat challenge. The change in postprandial chylomicron kinetics could not be explained by changes in insulin sensitivity, which appeared to be similar before and after intervention with either diet.
Conclusions
Daily moderate consumption of a lean red meat protein-enriched diet attenuates postprandial chylomicronaemia in response to ingestion of a fatty meal.
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